Severe hospital events following symptomatic infection with Sars-CoV-2 Omicron and Delta variants in France, December 2021-January 2022: A retrospective, population-based, matched cohort study.
Severe hospital events following symptomatic infection with Sars-CoV-2 Omicron and Delta variants in France, December 2021-January 2022: A retrospective, population-based, matched cohort study.
复制标题
DOI：
10.1016/j.eclinm.2022.101455
复制
发表时间：
2022-06
影响因子：
15.1
通讯作者：
中科院分区：
文献类型：
--
作者：
2021年12月法国出现SARS-CoV-2 Omicron变异株（亚系BA.1）发病率快速上升，而Delta变异株自2021年7月开始流行。我们的目的是确定Omicron与Delta在症状性SARS-CoV-2感染后发生严重医院事件的风险是否不同。我们进行了一项回顾性队列研究，比较根据病毒学诊断周数和年龄匹配的Omicron和Delta症状病例之间的严重医院事件（入住重症监护室或死亡）。使用考克斯比例风险模型，根据年龄、性别、疫苗接种状态、合并症的存在和居住地区调整分析。在2021年6月12日至2022年1月28日期间，纳入了184364例病例，其中931例发生了重度医院事件（822例Delta，109例Omicron）。Omicron与Delta病例之间的重度事件风险较低;两种变体之间的严重程度差异随年龄的增加而降低（40-64岁之间的校正风险比（aHR）=0·13 95%CI：0·08-0·20，80+岁之间的aHR=0·50 95%CI：0·26- 0·98）。重度事件的风险随着合并症的存在而增加（对于极高危合并症，40-64岁之间的aHR= 4.1595%CI：2.86 - 6.01）和男性（40-64岁年龄组aHR=2·28 95%CI：1·82-2·85），未接种组高于初免组（40- 64岁年龄组aHR=7·29 95%CI：5·58-9·54）。加强剂量可降低感染Omicron的80岁以上患者发生严重住院事件的风险（aHR= 0.29; 95%CI：0.12 - 0.69）。本研究证实Omicron的严重度低于Delta。然而，老年人疾病严重程度的差异不太明显。需要进一步的研究来更好地了解年龄和变异严重程度之间的相互作用。本研究作为法国公共卫生部常规工作的一部分进行。
A rapid increase in incidence of the SARS-CoV-2 Omicron variant (sub-lineage BA.1) occurred in France in December 2021, while the Delta variant was prevailing since July 2021. We aimed to determine whether the risk of a severe hospital event following symptomatic SARS-CoV-2 infection differs for Omicron versus Delta. We conducted a retrospective cohort study to compare severe hospital events (admission to intensive care unit or death) between Omicron and Delta symptomatic cases matched according to week of virological diagnosis and age. The analysis was adjusted for age, sex, vaccination status, presence of comorbidities and region of residence, using Cox proportional hazards model. Between 06/12/2021–28/01/2022, 184 364 cases were included, of which 931 had a severe hospital event (822 Delta, 109 Omicron). The risk of severe event was lower among Omicron versus Delta cases; the difference in severity between the two variants decreased with age (adjusted Hazard Ratio (aHR)=0·13 95%CI: 0·08–0·20 among 40–64 years, aHR=0·50 95%CI: 0·26–0.98 among 80+ years). The risk of severe event increased with the presence of comorbidities (for very-high-risk comorbidity, aHR=4·15 95%CI: 2·86–6·01 among 40–64 years) and in males (aHR=2·28 95%CI: 1·82–2·85among 40–64 years) and was higher in unvaccinated compared to primo-vaccinated (aHR=7·29 95%CI: 5·58–9·54 among 40–64 years). A booster dose reduced the risk of severe hospital event in 80+ years infected with Omicron (aHR=0·29; 95%CI: 0·12–0·69). This study confirms the lower severity of Omicron compared to Delta. However, the difference in disease severity is less marked in the elderly. Further studies are needed to better understand the interactions between age and severity of variants. The study was performed as part of routine work at Public Health France.
登录
查看更多内容
影响因子：
64.8
作者：
Liu J;Chandrashekar A;Sellers D;Barrett J;Jacob-Dolan C;Lifton M;McMahan K;Sciacca M;VanWyk H;Wu C;Yu J;Collier AY;Barouch DH
通讯作者：
Barouch DH
DOI：
10.1016/s0140-6736(22)00462-7
发表时间：
2022-04-02
期刊：
Lancet (London, England)
影响因子：
--
作者：
Nyberg T;Ferguson NM;Nash SG;Webster HH;Flaxman S;Andrews N;Hinsley W;Bernal JL;Kall M;Bhatt S;Blomquist P;Zaidi A;Volz E;Aziz NA;Harman K;Funk S;Abbott S;COVID-19 Genomics UK (COG-UK) consortium;Hope R;Charlett A;Chand M;Ghani AC;Seaman SR;Dabrera G;De Angelis D;Presanis AM;Thelwall S
通讯作者：
Thelwall S
DOI：
10.1016/j.lanepe.2021.100087
发表时间：
2021-06
期刊：
The Lancet regional health. Europe
影响因子：
--
作者：
Lefrancq N;Paireau J;Hozé N;Courtejoie N;Yazdanpanah Y;Bouadma L;Boëlle PY;Chereau F;Salje H;Cauchemez S
通讯作者：
Cauchemez S
影响因子：
24.8
作者：
GeurtsvanKessel CH;Geers D;Schmitz KS;Mykytyn AZ;Lamers MM;Bogers S;Scherbeijn S;Gommers L;Sablerolles RSG;Nieuwkoop NN;Rijsbergen LC;van Dijk LLA;de Wilde J;Alblas K;Breugem TI;Rijnders BJA;de Jager H;Weiskopf D;van der Kuy PHM;Sette A;Koopmans MPG;Grifoni A;Haagmans BL;de Vries RD
通讯作者：
de Vries RD
面对潜在的持续感染，老化和终身维持T细胞子集。
DOI：
10.1038/nri2318
发表时间：
2008-07
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Nikolich-Zugich J
通讯作者：
Nikolich-Zugich J