Infection status of human parvovirus B19, cytomegalovirus and herpes simplex Virus-1/2 in women with first-trimester spontaneous abortions in Chongqing, China.
Infection status of human parvovirus B19, cytomegalovirus and herpes simplex Virus-1/2 in women with first-trimester spontaneous abortions in Chongqing, China.
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重庆地区妊娠早期自然流产妇女人细小病毒B19、巨细胞病毒和单纯疱疹病毒1/2感染状况分析
DOI：
10.1186/s12985-018-0988-5
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发表时间：
2018-04-23
期刊：
影响因子：
4.8
通讯作者：
Liao P
中科院分区：
文献类型：
--
作者：
Gao YL;Gao Z;He M;Liao P
细小病毒B19（B19 V）、巨细胞病毒（CMV）和单纯疱疹病毒1/2（HSV-1/2）感染可导致流产、死胎和非免疫性胎儿水肿等胎儿丢失。在中国重庆，很少有综合性研究调查由病毒感染引起的妊娠早期自然流产。本研究旨在探讨B19病毒、巨细胞病毒（CMV）和单纯疱疹病毒（HSV-1/2）在早孕自然流产患者中的感染情况及相应的免疫反应。100例年龄17 ~ 47岁的人工流产患者纳入本研究。根据生产商的建议，定性分析血浆样本（100）中B19 V、CMV和HSV-1/2（Virion\Serion，德国）的特异性IgG/IgM。实时荧光定量PCR检测B19 V、CMV和HSV-1/2 DNA。无标本B19 V、CMV和HSV-1/2 DNA阳性。血清学检测B19 V、CMV、HSV-1/2 IgG阳性率分别为30.0%、95.0%、92.0%; B19 V、HSV-1/2 IgM阳性率分别为2%、1%。本研究中大部分流产患者病毒DNA检出率低，CMV和HSV-1/2 IgG阳性率高，提示B19 V、CMV和HSV-1/2可能不是导致早孕自然流产的共同因素。
Infection with Parvovirus B19 (B19V), Cytomegalovirus (CMV) and Herpes Simplex Virus-1/2 (HSV-1/2) may cause fetal loses including spontaneous abortion, intrauterine fetal death and non-immune hydrops fetalis. Few comprehensive studies have investigated first-trimester spontaneous abortions caused by virus infections in Chongqing, China. Our study intends to investigate the infection of B19V, CMV and HSV-1/2 in first-trimester spontaneous abortions and the corresponding immune response. 100 abortion patients aged from 17 to 47 years were included in our study. The plasma samples (100) were analyzed qualitatively for specific IgG/IgM for B19V, CMV and HSV-1/2 (Virion\Serion, Germany) according to the manufacturer’s recommendations. B19V, CMV and HSV-1/2 DNA were quantification by Real-Time PCR. No specimens were positive for B19V, CMV, and HSV-1/2 DNA. By serology, 30.0%, 95.0%, 92.0% of patients were positive for B19V, CMV and HSV-1/2 IgG respectively, while 2% and 1% for B19V and HSV-1/2 IgM. The low rate of virus DNA and a high proportion of CMV and HSV-1/2 IgG for most major of abortion patients in this study suggest that B19V, CMV and HSV-1/2 may not be the common factor leading to the spontaneous abortion of early pregnancy.
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影响因子：
2.9
作者：
Ke, Ling;He, Miao;Li, Wuping
通讯作者：
Li, Wuping
DOI：
10.1016/s0950-3552(05)80077-x
发表时间：
1991-03-01
期刊：
BAILLIERES CLINICAL OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
CHARD, T
通讯作者：
CHARD, T
影响因子：
7.3
作者：
Ball, E;Bulmer, JN;Robson, SC
通讯作者：
Robson, SC
影响因子：
3
作者：
Enders, M;Weidner, A;Enders, G
通讯作者：
Enders, G
影响因子：
6.7
作者：
Matovina, M;Husnjak, K;Grce, M
通讯作者：
Grce, M