Experimental Preeclampsia Causes Long-Lasting Hippocampal Vascular Dysfunction and Memory Impairment.
Experimental Preeclampsia Causes Long-Lasting Hippocampal Vascular Dysfunction and Memory Impairment.
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DOI：
10.3389/fphys.2022.889918
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发表时间：
2022
影响因子：
4
通讯作者：
Cipolla, Marilyn J.
中科院分区：
文献类型：
--
作者：
Johnson, Abbie C.;Tremble, Sarah M.;Cipolla, Marilyn J.
S说，子痫前期(PE)是一种妊娠期高血压疾病，在40岁至40岁之间的女性中，这种疾病与记忆力受损、认知能力下降和晚年脑萎缩有关。子痫前期会使患血管性痴呆的风险增加三倍，但PE对涉及记忆和认知的脆弱大脑区域(如海马体)血管系统的长期影响尚不清楚。在这里，我们使用了一种实验性PE(EPE)的大鼠模型，从妊娠第7天开始，通过维持大鼠2%的胆固醇饮食来研究以后生活中的海马区功能。在正常妊娠和EPE(n=8)后5个月测定SD大鼠的海马区依赖记忆和海马区小动脉(HA)功能。患有EPE的大鼠患有高血压，并且HAS对参与匹配神经元活动和局部血流(即神经血管耦合)的介质的血管反应性受损。EPE大鼠的长期记忆也受到了损害，但空间记忆没有受到影响。因此，这种EPE模型模拟了一些发生在以前进行过PE的女性身上的长期心血管和认知后果。这些发现提示PE后几个月存在HAS的内皮和血管平滑肌功能障碍，可能损害海马神经血管偶联。这代表了一种新的血管机制，PE通过这种机制导致早发性痴呆。
Preeclampsia (PE) is a hypertensive disorder of pregnancy that is associated with memory impairment, cognitive decline and brain atrophy later in life in women at ages as young as early-to-mid 40 s. PE increases the risk of vascular dementia three-fold, however, long-lasting effects of PE on the vasculature of vulnerable brain regions involved in memory and cognition, such as the hippocampus, remain unknown. Here, we used a rat model of experimental PE (ePE) induced by maintaining rats on a 2% cholesterol diet beginning on day 7 of gestation to investigate hippocampal function later in life. Hippocampal-dependent memory and hippocampal arteriole (HA) function were determined in Sprague Dawley rats 5 months after either a healthy pregnancy or ePE (n = 8/group). Rats that had ePE were hypertensive and had impaired vasoreactivity of HAs to mediators involved in matching neuronal activity with local blood flow (i.e., neurovascular coupling). ePE rats also had impaired long-term memory, but not spatial memory. Thus, this model of ePE mimics some of the long-lasting cardiovascular and cognitive consequences that occur in women who previously had PE. These findings suggest endothelial and vascular smooth muscle dysfunction of HAs were present months after PE that could impair hippocampal neurovascular coupling. This represents a novel vascular mechanism by which PE causes early-onset dementia.
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影响因子：
1.1
作者：
Abo El-Khair DM;El-Safti Fel-N;Nooh HZ;El-Mehi AE
通讯作者：
El-Mehi AE
影响因子：
20.1
作者：
Iadecola, Costantino;Gottesman, Rebecca F.
通讯作者：
Gottesman, Rebecca F.
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9.8
作者：
Fields JA;Garovic VD;Mielke MM;Kantarci K;Jayachandran M;White WM;Butts AM;Graff-Radford J;Lahr BD;Bailey KR;Miller VM
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Miller VM
影响因子：
2.7
作者：
Ledreux A;Wang X;Schultzberg M;Granholm AC;Freeman LR
通讯作者：
Freeman LR
影响因子：
1.9
作者：
Duva, CA;Floresco, SB;Phillips, AG
通讯作者：
Phillips, AG