The development of nasal polyp disease involves early nasal mucosal inflammation and remodelling.
The development of nasal polyp disease involves early nasal mucosal inflammation and remodelling.
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鼻息肉疾病的发展涉及早期鼻粘膜炎症和重塑
DOI：
10.1371/journal.pone.0082373
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zhang N
中科院分区：
文献类型：
--
作者：
Meng J;Zhou P;Liu Y;Liu F;Yi X;Liu S;Holtappels G;Bachert C;Zhang N
慢性鼻窦炎伴鼻息肉 (CRSwNP) 的特点是慢性炎症和组织重塑。表现为细胞外基质蛋白沉积、基底膜增厚、杯状细胞增生和上皮下水肿，血管和腺体减少。尽管重塑通常被认为是持续性炎症的结果，但息肉发展中炎症和重塑之间的时间顺序和关系仍不清楚。因此，我们的研究目的是通过比较5例双侧息肉病患者的局限于中鼻甲的早期鼻息肉（称为中鼻甲CRSwNP）、6例CRSwNP患者的成熟筛窦息肉和正常鼻粘膜的炎症和重塑的特异性标志物，探讨鼻息肉发展中普遍存在的病理特征，并阐明炎症和重塑之间的时间顺序和关系。来自 6 个对照受试者的组织。与成熟筛窦息肉和正常鼻粘膜相比，中鼻甲 CRSwNP 表现出明显更严重的上皮损失。与健康粘膜相比，成熟筛窦息肉中上皮细胞连接分子 E-钙粘蛋白、ZO-1 和 Occludin 的表达量也显着降低。中鼻甲CRSwNP的进一步特征是上皮下嗜酸性粒细胞和M2型巨噬细胞数量显着增加，息肉部分明显缺乏胶原蛋白和纤连蛋白沉积。相比之下，中鼻甲CRSwNP的鼻甲区域的特征是表达α-SMA和波形蛋白的TGF-β激活的肌成纤维细胞增加、pSmad2阳性细胞数量增加以及胶原沉积增加。这些发现表明 CRSwNP 的形成过程存在复杂的网络过程；包括大体上皮损伤和修复反应、嗜酸性粒细胞和巨噬细胞浸润以及组织重塑。此外，重塑似乎是并行发生的，而不是在炎症之后发生。
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by both a chronic inflammation and tissue remodelling; as indicated by extracellular matrix protein deposition, basement membrane thickening, goblet cell hyperplasia and subepithelial edema, with reduced vessels and glands. Although remodelling is generally considered to be consequence of persistent inflammation, the chronological order and relationship between inflammation and remodelling in polyp development is still not clear. The aim of our study was therefore to investigate the pathological features prevalent in the development of nasal polyps and to elucidate the chronological order and relationship between inflammation and remodelling, by comparing specific markers of inflammation and remodelling in early stage nasal polyps confined to the middle turbinate (refer to as middle turbinate CRSwNP) obtained from 5 CRSwNP patients with bilateral polyposis, mature ethmoidal polyps from 6 CRSwNP patients, and normal nasal mucosal tissue from 6 control subjects. Middle turbinate CRSwNP demonstrated significantly more severe epithelial loss compared to mature ethmoidal polyps and normal nasal mucosa. The epithelial cell junction molecules E-cadherin, ZO-1 and occludin were also expressed in significantly lower amounts in mature ethmoidal polyps compared to healthy mucosa. Middle turbinate CRSwNP were further characterized by significantly increased numbers of subepithelial eosinophils and M2 type macrophages, with a distinct lack of collagen and deposition of fibronectin in polyp part. In contrast, the turbinate area of the middle turbinate CRSwNP was characterized by an increase in TGF-β activated myofibroblasts expressing α-SMA and vimentin, an increase in the number of pSmad2 positive cells, as well as increased deposition of collagen. These findings suggest a complex network of processes in the formation of CRSwNP; including gross epithelial damage and repair reactions, eosinophil and macrophage cell infiltration, and tissue remodelling. Furthermore, remodelling appears to occur in parallel, rather than subsequent to inflammation.
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影响因子：
4.4
作者：
Martinez, Fernando O.;Gordon, Siamon;Mantovani, Alberto
通讯作者：
Mantovani, Alberto
DOI：
10.1164/rccm.200907-1071oc
发表时间：
2010-05-01
影响因子：
24.7
作者：
Kicic, Anthony;Hallstrand, Teal S.;Knight, Darryl A.
通讯作者：
Knight, Darryl A.
影响因子：
4
作者：
Marzioni, D;Banita, M;Castellucci, M
通讯作者：
Castellucci, M
影响因子：
2
作者：
Juniantito, Vetnizah;Izawa, Takeshi;Yamate, Jyoji
通讯作者：
Yamate, Jyoji
影响因子：
1.4
作者：
Lee, Heung-Man;Kang, Hee Jun;Cho, Jae Hoon
通讯作者：
Cho, Jae Hoon