The influence of medium elasticity on the prediction of histotripsy-induced bubble expansion and erythrocyte viability.
The influence of medium elasticity on the prediction of histotripsy-induced bubble expansion and erythrocyte viability.
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DOI：
10.1088/1361-6560/aab79b
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发表时间：
2018-05-02
影响因子：
3.5
通讯作者：
Bader KB
中科院分区：
文献类型：
--
作者：
Bader KB
组织切片是一种治疗性超声，通过声空化使组织机械液化。气泡膨胀在组织切片治疗的疗效中起着至关重要的作用，而空化动力学受介质弹性的强烈影响。在这项研究中，一个分析模型，预测组织诱导的气泡膨胀在流体中扩展到包括介质弹性的影响。在分析模型的预测和利用高度非线性激励（冲击散射直方图）和纯拉伸脉冲（微行程图）的数值计算之间观察到良好的一致性。当弹性模量大于20 MPa，峰值负压小于50 MPa时，两种形式的组构图均未计算气泡膨胀。由于单个气泡的膨胀，介质中的应变也被制成表格。根据红血球脉冲拉伸的经验数据，计算红血球与泡壁距离的函数。红细胞在距离泡壁44 μm的范围内仍保持活力。随着介质弹性的增加，气泡膨胀引起的应变对红细胞的影响距离显著减小。这些结果突出了组织弹性与组织切片疗效之间的关系。此外，确定了一个中弹性上限，超过该上限，组织切片法可能对组织液化无效。
Histotripsy is a form of therapeutic ultrasound that liquefies tissue mechanically via acoustic cavitation. Bubble expansion is paramount in the efficacy of histotripsy therapy, and the cavitation dynamics are strongly influenced by the medium elasticity. In this study, an analytic model to predict histotripsy-induced bubble expansion in a fluid was extended to include the effects of medium elasticity. Good agreement was observed between the predictions of the analytic model and numerical computations utilizing highly nonlinear excitations (shock-scattering histotripsy) and purely tensile pulses (microtripsy). No bubble expansion was computed for either form of histotripsy when the elastic modulus was greater than 20 MPa and the peak negative pressure was less than 50 MPa. Strain in the medium due to the expansion of a single bubble was also tabulated. The viability of red blood cells was calculated as a function of distance from the bubble wall based on empirical data of impulsive stretching of erythrocytes. Red blood cells remained viability at distances further than 44 μm from the bubble wall. As the medium elasticity increased, the distance over which bubble expansion-induced strain influenced red blood cells was found to decrease sigmoidally. These results highlight the relationship between tissue elasticity and the efficacy of histotripsy. In addition, an upper medium elasticity limit was identified, above which histotripsy may not be effective for tissue liquefaction.
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影响因子：
3.5
作者：
Bader KB;Holland CK
通讯作者：
Holland CK
影响因子：
3.3
作者：
Gent, AN
通讯作者：
Gent, AN
影响因子：
3.5
作者：
Bader KB;Haworth KJ;Shekhar H;Maxwell AD;Peng T;McPherson DD;Holland CK
通讯作者：
Holland CK
DOI：
10.1098/rspa.1959.0016
发表时间：
1959-01-01
影响因子：
--
作者：
GENT, AN;LINDLEY, PB
通讯作者：
LINDLEY, PB
DOI：
10.1196/annals.1363.006
发表时间：
2005-01-01
期刊：
CELL INJURY: MECHANISMS, RESPONSES, AND REPAIR
影响因子：
--
作者：
Barbee, Kenneth A.
通讯作者：
Barbee, Kenneth A.