Interference of tactile and pain stimuli on thalamocortical signal processing in humans revealed by median nerve SEPs
Interference of tactile and pain stimuli on thalamocortical signal processing in humans revealed by median nerve SEPs
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正中神经 SEP 揭示触觉和疼痛刺激对人类丘脑皮质信号处理的干扰
DOI：
10.1016/j.clinph.2007.08.008
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发表时间：
2007
影响因子：
4.7
通讯作者：
T. Waberski
中科院分区：
文献类型：
--
作者：
R. Gobbelé;P. Halboni;H. Buchner;T. Waberski
目的研究触觉和疼痛刺激对人体早期体感诱发电位（sep）的干扰，包括高频振荡（HFOs），以进一步研究丘脑皮质对体感信息的加工。方法分别在(1)无干扰、(2)对2、3号指进行触觉干扰、(3)对同一指施加疼痛时记录多通道正中神经sep。时空源分析分离了脑干（S1）、丘脑（S2）和两个皮层源（S3、S4），分别对信号的低（20-450Hz）和高（450-750Hz）频率部分进行了评估。结果两种情况下，慢频sep均显示皮层源S3的活动减少，而丘脑源S2的活动在疼痛干扰时显著增加。在两种干扰下，hfo均表现出皮层源S3增加，丘脑源S2和皮层源S4增加的趋势。结论：虽然疼痛刺激可能不是特定于伤害性事件，但目前的数据证实，在初级感觉皮层（3b区，1区）的感觉信息加工的早期阶段，疼痛的处理类似于感觉干扰。意义hfo可能代表一种内在的“体感警报”系统，该系统以类似的方式对两种干扰刺激作出反应，因此表明没有定性评估的干扰。
OBJECTIVEWe investigated the interference of tactile and painful stimuli on human early somatosensory evoked potentials (SEPs) including high frequency oscillations (HFOs) to further study thalamocortical processing of somatosensory information.METHODSMulti-channel median nerve SEPs were recorded during (1) no interference, (2) sensory interference by tactile stimulation to digits 2 and 3, and (3) application of pain to the same digits. Spatio-temporal source analysis separated brain stem (S1), thalamic (S2) and two cortical sources (S3, S4), which were evaluated for the low (20–450Hz) and high (450–750Hz) frequency portion of the signal.RESULTSLow frequency SEPs showed a decrease of activity at cortical source S3 during both conditions, while thalamic source S2 was significantly increased during pain interference. HFOs showed an increase of cortical source S3 and in trend of thalamic source S2 and cortical source S4 during both kinds of interference.CONCLUSIONSAlthough the painful stimulus might not be specific for the nociceptive afferents, the present data affirm that at this early stage of sensory information processing within the primary sensory cortex (area 3b, area 1) pain is handled similar to sensory interference.SIGNIFICANCEHFOs might represent an intrinsic “somatosensory alerting” system which reacts to both interference stimuli in a similar way, therefore indicating an interference without a qualitative evaluation.
影响因子：
2.5
作者：
Ikeda, H;Leyba, L;Okada, YC
通讯作者：
Okada, YC
影响因子：
2.5
作者：
Jones, MS;MacDonald, KD;Barth, DS
通讯作者：
Barth, DS
影响因子：
2.5
作者：
Jones, MS;Barth, DS
通讯作者：
Barth, DS