MEF2 is an in vivo immune-metabolic switch.
MEF2 is an in vivo immune-metabolic switch.
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MEF2是一个体内免疫代谢开关。
DOI：
10.1016/j.cell.2013.09.007
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发表时间：
2013-10-10
期刊：
影响因子：
64.5
通讯作者：
Dionne MS
中科院分区：
文献类型：
--
作者：
Clark RI;Tan SW;Péan CB;Roostalu U;Vivancos V;Bronda K;Pilátová M;Fu J;Walker DW;Berdeaux R;Geissmann F;Dionne MS
Infections disturb metabolic homeostasis in many contexts, but the underlying connections are not completely understood. To address this, we use paired genetic and computational screens in Drosophila to identify transcriptional regulators of immunity and pathology and their associated target genes and physiologies. We show that Mef2 is required in the fat body for anabolic function and the immune response. Using genetic and biochemical approaches, we find that MEF2 is phosphorylated at a conserved site in healthy flies and promotes expression of lipogenic and glycogenic enzymes. Upon infection, this phosphorylation is lost, and the activity of MEF2 changes—MEF2 now associates with the TATA binding protein to bind a distinct TATA box sequence and promote antimicrobial peptide expression. The loss of phosphorylated MEF2 contributes to loss of anabolic enzyme expression in Gram-negative bacterial infection. MEF2 is thus a critical transcriptional switch in the adult fat body between metabolism and immunity. Mef2 is required in Drosophila for immune function and storage of fat and glycogen MEF2 is phosphorylated in vivo at a conserved site (T20) to promote anabolism Infection reduces phospho-T20, allowing MEF2 to bind TBP and an immune TATA box MEF2 dephosphorylation leads to metabolic dysfunction in Gram-negative infection The transcription factor MEF2 acts as a central switch between metabolic and immune functions in Drosophila, shifting upon infection from activation of anabolic enzymes to immune response genes.
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影响因子：
9.2
作者：
Clark, Rebecca I.;Woodcock, Katie J.;Geissmann, Frederic;Trouillet, Celine;Dionne, Marc S.
通讯作者：
Dionne, Marc S.
影响因子：
16
作者：
Hedengren, M;Åsling, B;Hultmark, D
通讯作者：
Hultmark, D
DOI：
10.1523/jneurosci.2688-09.2010
发表时间：
2010-04-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Blanchard FJ;Collins B;Cyran SA;Hancock DH;Taylor MV;Blau J
通讯作者：
Blau J
影响因子：
82.9
作者：
Berdeaux, Rebecca;Goebel, Naomi;Montminy, Marc
通讯作者：
Montminy, Marc
DOI：
10.1142/s0219720005001375
发表时间：
2005-08-01
影响因子：
1
作者：
Futschik, Matthias E.;Carlisle, Bronwyn
通讯作者：
Carlisle, Bronwyn