The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas.

The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas.
复制标题

DOI:
10.1016/j.neuron.2017.10.007
复制
发表时间:
2017-11-01
期刊:
影响因子:
16.2
通讯作者:
Zeng H
Zeng H
中科院分区:
医学1区
文献类型:
--
作者:
Ecker JR;Geschwind DH;Kriegstein AR;Ngai J;Osten P;Polioudakis D;Regev A;Sestan N;Wickersham IR;Zeng H

文献摘要

参考文献

被引文献

相似文献

神经元细胞类型、分布和连接模式的全面表征对于理解神经回路的特性及其如何产生行为至关重要。在这里,我们回顾了 BRAIN Initiative 细胞普查联盟(由美国 BRAIN Initiative 资助的 10 个试点项目)在开发、验证和扩大新兴基因组和解剖图谱技术方面的经验,以创建神经元细胞类型及其在多个物种和发育过程中的联系的完整清单。这些项目为更大规模、更长期地生成小鼠和人类等物种的全脑细胞图谱奠定了基础。在这个观点中,埃克等人。讨论 BRAIN Initiative 细胞普查联盟的工作,该联盟有 10 个试点项目,其共同目标是开发和验证生成哺乳动物大脑神经元细胞类型综合图谱的方法。
A comprehensive characterization of neuronal cell types, their distributions and patterns of connectivity is critical for understanding the properties of neural circuits and how they generate behaviors. Here we review the experiences of the BRAIN Initiative Cell Census Consortium – ten pilot projects funded by the U.S. BRAIN Initiative – in developing, validating and scaling up emerging genomic and anatomical mapping technologies for creating a complete inventory of neuronal cell types and their connections in multiple species and during development. These projects lay the foundation for a larger and longer-term effort to generate whole-brain cell atlases in species including mice and humans. In this Perspective, Ecker et al. discuss the efforts of the BRAIN Initiative Cell Census Consortium, ten pilot projects whose collective goal was to develop and validate methods for generating comprehensive atlases of neuronal cell types in the mammalian brain.
DOI: 10.1016/j.conb.2016.10.003
发表时间: 2017-03
影响因子: 5.7
作者:
Bandler RC;Mayer C;Fishell G
通讯作者: Fishell G
DOI: 10.1038/mp.2016.158
发表时间: 2016-11
影响因子: 11
作者:
Bardy, C.;van den Hurk, M.;Kakaradov, B.;Erwin, J. A.;Jaeger, B. N.;Hernandez, R. V.;Eames, T.;Paucar, A. A.;Gorris, M.;Marchand, C.;Jappelli, R.;Barron, J.;Bryant, A. K.;Kellogg, M.;Lasken, R. S.;Rutten, B. P. F.;Steinbusch, H. W. M.;Yeo, G. W.;Gage, F. H.
通讯作者: Gage, F. H.
DOI: 10.1038/nn.4593
发表时间: 2017-08
影响因子: 25
作者:
Chan KY;Jang MJ;Yoo BB;Greenbaum A;Ravi N;Wu WL;Sánchez-Guardado L;Lois C;Mazmanian SK;Deverman BE;Gradinaru V
通讯作者: Gradinaru V
DOI: 10.1038/nbt.3445
发表时间: 2016-02
影响因子: 46.9
作者:
Cadwell CR;Palasantza A;Jiang X;Berens P;Deng Q;Yilmaz M;Reimer J;Shen S;Bethge M;Tolias KF;Sandberg R;Tolias AS
通讯作者: Tolias AS
DOI: 10.1073/pnas.0509032102
发表时间: 2005-12-06
影响因子: 11.1
作者:
Chen, JG;Rasin, MR;Sestan, N
通讯作者: Sestan, N