A single dose investigational subunit vaccine for human use against Nipah virus and Hendra virus.
A single dose investigational subunit vaccine for human use against Nipah virus and Hendra virus.
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DOI：
10.1038/s41541-021-00284-w
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发表时间：
2021-02-08
期刊：
影响因子：
9.2
通讯作者：
Dimitrov AS
中科院分区：
文献类型：
--
作者：
Geisbert TW;Bobb K;Borisevich V;Geisbert JB;Agans KN;Cross RW;Prasad AN;Fenton KA;Yu H;Fouts TR;Broder CC;Dimitrov AS
尼帕病毒和亨德拉病毒是高致病性蝙蝠传播的副粘病毒，最近被列入世卫组织蓝图优先疾病清单。自2012年以来，一种完全注册的马抗亨德拉病毒亚单位疫苗已在澳大利亚使用。基于相同的免疫原，亨德拉病毒附着糖蛋白胞外域，一种用于人的亚单位疫苗制剂现在处于I期临床试验中。我们报告说，这种人用疫苗制剂的单剂量接种方案在非人灵长类动物模型中可防止亨德拉病毒或尼帕病毒的致命攻击。针对尼帕孟加拉国菌株的保护在用0.1 mg蛋白亚基的低剂量免疫后7天就开始。我们的数据表明，这种人用疫苗可用作有效的紧急疫苗，以破坏尼帕病在爆发环境中的潜在传播。
Nipah and Hendra viruses are highly pathogenic bat-borne paramyxoviruses recently included in the WHO Blueprint priority diseases list. A fully registered horse anti-Hendra virus subunit vaccine has been in use in Australia since 2012. Based on the same immunogen, the Hendra virus attachment glycoprotein ectodomain, a subunit vaccine formulation for use in people is now in a Phase I clinical trial. We report that a single dose vaccination regimen of this human vaccine formulation protects against otherwise lethal challenges of either Hendra or Nipah virus in a nonhuman primate model. The protection against the Nipah Bangladesh strain begins as soon as 7 days post immunization with low dose of 0.1 mg protein subunit. Our data suggest this human vaccine could be utilized as efficient emergency vaccine to disrupt potential spreading of Nipah disease in an outbreak setting.
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