Pain sensitivity and pain reactivity in osteoarthritis.
Pain sensitivity and pain reactivity in osteoarthritis.
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DOI：
10.1002/acr.20373
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发表时间：
2011-03
影响因子：
4.7
通讯作者：
Edwards, Robert R.
中科院分区：
文献类型：
--
作者：
Lee, Yvonne C.;Lu, Bing;Bathon, Joan M.;Haythornthwaite, Jennifer A.;Smith, Michael T.;Page, Gayle G.;Edwards, Robert R.
In systemic inflammatory diseases such as rheumatoid arthritis, pain and inflammation exhibit reciprocal inter-relationships. However, the nature of the association between pain and inflammation in osteoarthritis (OA) is not clear. We assessed experimental pain sensitivity and compared the inflammatory response to pain in 26 OA patients and 33 age-and sex-matched controls from the general population. Participants underwent psychophysical pain testing to assess pain sensitivity in response to heat, cold and mechanical stimuli. Blood samples were taken at baseline and four time points after testing to determine the effect of acute pain on C-reactive protein (CRP), interleukin 6 (IL-6), interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α). OA patients had lower pressure pain thresholds (P ≤ 0.003) and higher heat pain ratings (P ≤ 0.04) than controls across multiple body sites. OA patients had higher CRP levels than controls (P = 0.007). CRP levels did not change in response to pain testing. Although not statistically significant, OA patients tended to have higher IL-6 levels than controls (P = 0.12). IL-6 levels increased after pain testing in OA patients and controls (P < 0.0001), but the amount of increase was not different between the two groups. Among OA patients, heightened pain sensitivity was associated with elevated CRP and IL-6 (P ≤ 0.05). Compared to controls, OA patients are more sensitive to experimental pain at multiple body sites. IL-6 levels in OA patients and controls exhibited reactivity to acute painful stimuli, increasing at similar rates after psychophysical pain testing.
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影响因子：
--
作者：
Livshits, Gregory;Zhai, Guangju;Hart, Deborah J.;Kato, Bernet S.;Wang, Huizhong;Williams, Frances M. K.;Spector, Tim D.
通讯作者：
Spector, Tim D.
影响因子：
7.4
作者：
LAUTENBACHER, S;ROLLMAN, GB;MCCAIN, GA
通讯作者：
MCCAIN, GA
影响因子：
2.5
作者：
Geiss, A;Varadi, E;Anton, F
通讯作者：
Anton, F
DOI：
10.1002/art.24120
发表时间：
2008-10-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Imamura, Marta;Imamura, Satiko Tomikawa;Camanho, Gilberto Luis
通讯作者：
Camanho, Gilberto Luis
影响因子：
7.4
作者：
Geiss, A;Rohleder, N;Anton, F
通讯作者：
Anton, F