Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study.
Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study.
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DOI：
10.1002/art.24598
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发表时间：
2009-07
影响因子：
--
通讯作者：
Spector, Tim D.
中科院分区：
文献类型：
--
作者：
Livshits, Gregory;Zhai, Guangju;Hart, Deborah J.;Kato, Bernet S.;Wang, Huizhong;Williams, Frances M. K.;Spector, Tim D.
目前，迫切需要鉴定能够改善早期骨关节炎（OA）预测的生物标志物。我们进行了这项研究，以确定白细胞介素-6（IL-6）、肿瘤坏死因子α（TNFα）和C反应蛋白（CRP）的循环水平是否可以作为正常人群中放射学膝关节OA（RKOA）的有用标志物。RKOA数据来自Chingford研究的队列，这是一项针对健康中年英国女性的前瞻性人群研究。使用Kellgren/Lawrence（K/L）分级评估受试者的RKOA影响状态，根据基线（n = 908）以及10年和15年后获得的X线片确定。在5、8和15年时，使用高灵敏度商业测定法测定CRP、IL-6和TNFα的血清水平。将任一膝关节的K/L分级≥2用作结局指标。统计分析包括重复测量的方差分析和逻辑回归模型，以及二分响应的纵向建模。在15年的随访中，RKOA（K/L ≥2级）的患病率从14.7%增加到48.7%（与基线相比P < 0.00001）。在被诊断为RKOA的受试者中，体重指数（BMI）和CRP和IL-6的循环水平始终显著较高。当对数据进行多元logistic回归分析时，年龄较大（P = 3.93 × 10−5）、基线时BMI较高（P = 0.0003）和第5年IL-6水平升高（P = 0.0129）的变量被确定为第10年出现RKOA的独立预测因素。使用对3次访视获得的数据进行重复测量的纵向建模，充分证实了结果。在IL-6水平处于递增水平的第四个四分位数（相对于第一个四分位数）的受试者中，RKOA的比值比为2.74（95%置信区间1.94-3.87）。这项后续研究表明，如果个体具有较高的BMI和增加的IL-6循环水平，则更有可能被诊断为RKOA。这些结果应该刺激更多的工作IL-6作为一个潜在的治疗靶点。
There is a great need for identification of biomarkers that could improve the prediction of early osteoarthritis (OA). We undertook this study to determine whether circulating levels of interleukin-6 (IL-6), tumor necrosis factor α (TNFα), and C-reactive protein (CRP) can serve as useful markers of radiographic knee OA (RKOA) in a normal human population. RKOA data were obtained from the cohort of the Chingford Study, a prospective population-based study of healthy, middle-aged British women. The RKOA-affected status of the subjects was assessed using the Kellgren/Lawrence (K/L) grade as determined on radiographs obtained at baseline (n = 908) and at 10 years and 15 years thereafter. Serum levels of CRP, IL-6, and TNFα were assayed at 5, 8, and 15 years, using high-sensitivity commercial assays. A K/L grade of ≥2 in either knee was used as the outcome measure. Statistical analyses included analysis of variance for repeated measurements and logistic regression models, together with longitudinal modeling of dichotomous responses. During 15 years of followup, the prevalence of RKOA (K/L grade ≥2) increased from 14.7% to 48.7% (P < 0.00001 versus baseline). The body mass index (BMI) and circulating levels of CRP and IL-6 were consistently and significantly higher in subjects diagnosed as having RKOA. When multiple logistic regression was applied to the data, the variables of older age (P = 3.93 × 10−5), higher BMI at baseline (P = 0.0003), and increased levels of IL-6 at year 5 (P = 0.0129) were determined to be independent predictors of the appearance of RKOA at year 10. The results were fully confirmed using longitudinal modeling of repeated measurements of the data obtained at 3 visits. The odds ratio for RKOA in subjects whose IL-6 levels were in the fourth quartile of increasing levels (versus the first quartile) was 2.74 (95% confidence interval 1.94–3.87). This followup study showed that individuals were more likely to be diagnosed as having RKOA if they had a higher BMI and increased circulating levels of IL-6. These results should stimulate more work on IL-6 as a potential therapeutic target.
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影响因子：
27.4
作者：
Goldring MB;Otero M;Tsuchimochi K;Ijiri K;Li Y
通讯作者：
Li Y
影响因子：
7
作者：
Pearle, A. D.;Scanzello, C. R.;Crow, M. K.
通讯作者：
Crow, M. K.
影响因子：
5.1
作者：
Park, HS;Park, JY;Yu, R
通讯作者：
Yu, R
DOI：
10.1111/j.1532-5415.2004.52320.x
发表时间：
2004-07-01
影响因子：
6.3
作者：
Fisher, AL
通讯作者：
Fisher, AL
影响因子：
--
作者：
Spector, TD;Hart, DJ;Pepys, MB
通讯作者：
Pepys, MB