Visual space is represented by nonmatching topographies of distinct mouse retinal ganglion cell types.
Visual space is represented by nonmatching topographies of distinct mouse retinal ganglion cell types.
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DOI：
10.1016/j.cub.2013.12.020
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发表时间：
2014-02-03
期刊：
影响因子：
9.2
通讯作者：
Wong, Rachel O. L.
中科院分区：
文献类型：
--
作者：
Bleckert, Adam;Schwartz, Gregory W.;Turner, Maxwell H.;Rieke, Fred;Wong, Rachel O. L.
感觉回路中神经元的分布显示出有序的空间模式，这些空间模式被安排用于增强或编码外部环境的特定区域或特征。事实上，视觉空间在脊椎动物视网膜上的采样并不均匀。视网膜神经节细胞（RGC）密度增加，树突状乔木的大小减少与更高的采样频率的视网膜位置，如在灵长类动物的中央凹和中央区域的食肉动物。在这些位置中，在单个细胞的水平上获得更高的敏锐度，因为RGC的感受野中心大致对应于其树突状乔木的空间范围。对于大多数物种，结构和功能上不同的RGC类型似乎具有相似的地形;集体缩放其细胞密度和乔木大小朝向相同的视网膜位置。因此，视觉空间是由多个不同的回路在视网膜上并行表示的。相比之下，我们发现了一群被称为α或α样的小鼠RGCs，它们在细胞密度、大小和感受野中显示出鼻颞梯度，这有助于增强额叶视野中的视觉采样。与其他已知的小鼠RGC类型的α-样RGC的分布形成对比，并表明与大多数哺乳动物不同，小鼠中的RGC拓扑结构被安排为不同的采样空间。
The distributions of neurons in sensory circuits display ordered spatial patterns arranged to enhance or encode specific regions or features of the external environment. Indeed, visual space is not sampled uniformly across the vertebrate retina. Retinal ganglion cell (RGC) density increases and dendritic arbor size decreases towards retinal locations with higher sampling frequency, such as the fovea in primates and area centralis in carnivores. In these locations, higher acuity at the level of individual cells is obtained because the receptive field center of a RGC corresponds approximately to the spatial extent of its dendritic arbor. For most species, structurally and functionally distinct RGC types appear to have similar topographies; collectively scaling their cell densities and arbor sizes towards the same retina location. Thus, visual space is represented across the retina in parallel by multiple distinct circuits. In contrast, we find a population of mouse RGCs, known as alpha or alpha-like, that displays a nasal-to-temporal gradient in cell density, size and receptive fields, which facilitates enhanced visual sampling in frontal visual fields. The distribution of alpha-like RGCs contrasts with other known mouse RGC types, and suggests that unlike most mammals, RGC topographies in mice are arranged to sample space differentially.
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DOI：
10.1523/jneurosci.0907-11.2011
发表时间：
2011-05-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kay JN;De la Huerta I;Kim IJ;Zhang Y;Yamagata M;Chu MW;Meister M;Sanes JR
通讯作者：
Sanes JR
影响因子：
16.2
作者：
Chang, Le;Breuninger, Tobias;Euler, Thomas
通讯作者：
Euler, Thomas
影响因子：
2.5
作者：
Kong, JH;Fish, DR;Masland, RH
通讯作者：
Masland, RH
影响因子：
2.5
作者：
KIRBY, MA;CHALUPA, LM
通讯作者：
CHALUPA, LM
影响因子：
64.8
作者：
Kay, Jeremy N.;Chu, Monica W.;Sanes, Joshua R.
通讯作者：
Sanes, Joshua R.