Insulin resistance and metabolic syndrome in prepubertal boys with Klinefelter syndrome.
Insulin resistance and metabolic syndrome in prepubertal boys with Klinefelter syndrome.
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DOI：
10.1111/j.1651-2227.2011.02161.x
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Ross JL
中科院分区：
文献类型：
--
作者：
Bardsley MZ;Falkner B;Kowal K;Ross JL
探讨青春期前Klinefelter综合征男孩代谢综合征的危险因素。89名4-12.9岁的Klinefelter综合征男孩和34名年龄匹配的对照男孩测量了身高、体重、腰围和血压，他们的父母完成了一份关于体力活动的问卷。Klinefelter综合征的男孩也有血脂，空腹血糖和胰岛素的测量。计算胰岛素-葡萄糖稳态模型评估，并评估男孩的儿童代谢综合征。Klinefelter综合征组和对照组的年龄相似（7.5 ± 2.4岁vs. 8.1 ± 2.3岁）。体重指数测量结果相似，但30%的Klinefelter综合征男孩的腰围>90‰，而对照组为21%。Klinefelter综合征患者平均每天跑步时间比对照组少42分钟（p < 0.01）。大约37%的Klinefelter综合征男孩LDL胆固醇升高，24%有胰岛素抵抗，7%符合代谢综合征的三个诊断标准。躯干肥胖、胰岛素抵抗和代谢综合征存在于4-12岁的Klinefelter综合征男孩中，这些都与跑步活动减少有关。
To investigate risk factors for metabolic syndrome in prepubertal boys with Klinefelter syndrome. Eighty-nine boys with Klinefelter syndrome, ages 4–12.9 years, and 34 age-matched control boys had height, weight, waist circumference and blood pressure measured and their parents completed a questionnaire about physical activity. The boys with Klinefelter syndrome also had measurement of lipids, fasting glucose and insulin. Insulin-glucose homeostasis model assessment was calculated, and the boys were evaluated for childhood metabolic syndrome. The Klinefelter syndrome and control groups were similar ages (7.5 ± 2.4 vs. 8.1 ± 2.3 years). Body mass index measurements were similar, but waist circumference was >90‰ in 30% of boys with Klinefelter syndrome versus 21% of controls. The mean daily time spent running was 42 min less in the Klinefelter syndrome versus control groups (p < 0.01). About 37% of the boys with Klinefelter syndrome had elevated LDL cholesterol, 24% had insulin resistance, and 7% met the three criteria for diagnosis of metabolic syndrome. Truncal obesity, insulin resistance and metabolic syndrome are present in boys as young as 4–12 years with Klinefelter syndrome, and these occur in association with reduced running-type activity.
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影响因子：
37.8
作者：
de Ferranti, SD;Gauvreau, K;Rifai, N
通讯作者：
Rifai, N
影响因子：
5.2
作者：
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通讯作者：
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影响因子：
7.1
作者：
HAMILL, PVV;DRIZD, TA;MOORE, WM
通讯作者：
MOORE, WM
影响因子：
8
作者：
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通讯作者：
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影响因子：
8.2
作者：
MATTHEWS, DR;HOSKER, JP;TURNER, RC
通讯作者：
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