Does Breast Milk Nurture T Lymphocytes in Their Cradle?
Does Breast Milk Nurture T Lymphocytes in Their Cradle?
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DOI：
10.3389/fped.2018.00268
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发表时间：
2018
影响因子：
2.6
通讯作者：
Nanan R
中科院分区：
文献类型：
--
作者：
Hsu PS;Nanan R
母乳喂养在多个方面与改善婴儿结局有关，包括免疫结局，如感染和潜在的特应性和自身免疫。然而，相关性并不一定涉及因果关系，在这一点上，母乳喂养和母乳成分如何调节婴儿的免疫区室仍然不清楚，特别是在人类中。一些证据表明，母乳喂养会影响婴儿胸腺的发育，胸腺是T细胞发育的关键器官。这可能是母乳成分介导的直接影响，或者是母乳喂养对婴儿肠道微生物组影响的次要影响。在这里，我们讨论了母乳喂养和胸腺发育之间的这种关联的潜在机制和影响。
Breast feeding has been associated with improved infant outcomes in multiple aspects, including immune outcomes such as infections and potentially atopy and autoimmunity. However associations do not necessarily implicate cause and effect and at this point, exactly how breast feeding and components of breast milk may modulate the infant's immune compartment remains unclear, especially in humans. Some lines of evidence suggest that breastfeeding affects the development of the infant's thymus, a critical organ for T cell development. This may be a direct effect mediated by breast milk components or alternatively, a secondary effect from the impact of breast feeding on the infant's gut microbiome. Here we discuss the potential mechanisms and impact of this association between breast feeding and thymic development.
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影响因子：
4.4
作者：
Ghosh, Mrinal K.;Nguyen, Virginia;Walker, Ameae M.
通讯作者：
Walker, Ameae M.
影响因子：
5.7
作者：
Guaraldi F;Salvatori G
通讯作者：
Salvatori G
影响因子：
2.6
作者：
Ballard, Olivia;Morrow, Ardythe L.
通讯作者：
Morrow, Ardythe L.
影响因子：
3.8
作者：
Brenton, J. Nicholas;Engel, Casey E.;Goldman, Myla D.
通讯作者：
Goldman, Myla D.
DOI：
10.1084/jem.191.10.1807
发表时间：
2000-05-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Labéta MO;Vidal K;Nores JE;Arias M;Vita N;Morgan BP;Guillemot JC;Loyaux D;Ferrara P;Schmid D;Affolter M;Borysiewicz LK;Donnet-Hughes A;Schiffrin EJ
通讯作者：
Schiffrin EJ