Distinct Thalamo-Cortical Controls for Shoulder, Elbow, and Wrist during Locomotion.
Distinct Thalamo-Cortical Controls for Shoulder, Elbow, and Wrist during Locomotion.
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DOI：
10.3389/fncom.2013.00062
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发表时间：
2013
影响因子：
3.2
通讯作者：
Sirota MG
中科院分区：
文献类型：
--
作者：
Beloozerova IN;Stout EE;Sirota MG
最近的数据从这个实验室的差异控制的肩膀，肘部，手腕施加的丘脑-皮层网络在运动过程中，实验涉及长期仪表猫走在一个平面上，沿着一个水平的梯子。以下三组神经元的活性被表征：（1）投射到锥体束的运动皮质的神经元（PTNs），（2）腹外侧丘脑（VL）的神经元，许多被鉴定为投射到运动皮质（丘脑-皮质神经元，TC），和（3）抑制TC的丘脑网状核（RE）的神经元。神经元根据其感受野分为肩，肘，腕/爪相关的类别。在简单的运动，肩相关的PTNs是最活跃的后期站姿和早期摆动，并在阶梯上，往往增加活动和步幅相关的调制，同时减少放电持续时间。肘部相关的PTNs是最活跃的后期摆动/早期的立场，通常保持类似的梯子。腕部相关的PTNs在摆动过程中最活跃，并且在阶梯上经常减少活动并增加调制，同时减少放电持续时间。在VL中，肩相关神经元在从摆动到站立的过渡期间更加活跃。在从站立到摆动的过渡过程中，肘部相关细胞往往更活跃，在梯子上通常会降低它们的活性并增加调节。腕部相关神经元在整个站立阶段更加活跃。在RE中，肩相关细胞具有低放电率和调制深度，并且长时间的活动均匀分布在整个周期中。与此形成鲜明对比的是，手腕/爪相关的细胞在站立和摆动结束时同步放电，具有短时间的高活性，高调制和频繁的睡眠型爆发。我们的结论是，丘脑-皮层网络处理信息的前肢不同的不同部分，并施加不同的控制在肩膀，肘部和手腕在运动。
Recent data from this laboratory on differential controls for the shoulder, elbow, and wrist exerted by the thalamo-cortical network during locomotion is presented, based on experiments involving chronically instrumented cats walking on a flat surface and along a horizontal ladder. The activity of the following three groups of neurons is characterized: (1) neurons of the motor cortex that project to the pyramidal tract (PTNs), (2) neurons of the ventrolateral thalamus (VL), many identified as projecting to the motor cortex (thalamo-cortical neurons, TCs), and (3) neurons of the reticular nucleus of thalamus (RE), which inhibit TCs. Neurons were grouped according to their receptive field into shoulder-, elbow-, and wrist/paw-related categories. During simple locomotion, shoulder-related PTNs were most active in the late stance and early swing, and on the ladder, often increased activity and stride-related modulation while reducing discharge duration. Elbow-related PTNs were most active during late swing/early stance and typically remained similar on the ladder. Wrist-related PTNs were most active during swing, and on the ladder often decreased activity and increased modulation while reducing discharge duration. In the VL, shoulder-related neurons were more active during the transition from swing-to-stance. Elbow-related cells tended to be more active during the transition from stance-to-swing and on the ladder often decreased their activity and increased modulation. Wrist-related neurons were more active throughout the stance phase. In the RE, shoulder-related cells had low discharge rates and depths of modulation and long periods of activity distributed evenly across the cycle. In sharp contrast, wrist/paw-related cells discharged synchronously during the end of stance and swing with short periods of high activity, high modulation, and frequent sleep-type bursting. We conclude that thalamo-cortical network processes information related to different segments of the forelimb differently and exerts distinct controls over the shoulder, elbow, and wrist during locomotion.
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影响因子：
5.5
作者：
BELOOZEROVA, IN;SIROTA, MG
通讯作者：
SIROTA, MG
影响因子：
2.5
作者：
CHAMBERS, WW;LIU, CN
通讯作者：
LIU, CN
影响因子：
2.5
作者：
Beloozerova, IN;Sirota, MG
通讯作者：
Sirota, MG
影响因子：
2.5
作者：
Bretzner, F;Drew, T
通讯作者：
Drew, T
影响因子：
5.5
作者：
BUYS, EJ;LEMON, RN;MUIR, RB
通讯作者：
MUIR, RB