JNK regulates muscle remodeling via myostatin/SMAD inhibition.
JNK regulates muscle remodeling via myostatin/SMAD inhibition.
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DOI：
10.1038/s41467-018-05439-3
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发表时间：
2018-08-02
影响因子：
16.6
通讯作者：
Goodyear LJ
中科院分区：
文献类型：
--
作者：
Lessard SJ;MacDonald TL;Pathak P;Han MS;Coffey VG;Edge J;Rivas DA;Hirshman MF;Davis RJ;Goodyear LJ
Skeletal muscle has a remarkable plasticity to adapt and remodel in response to environmental cues, such as physical exercise. Endurance exercise stimulates improvements in muscle oxidative capacity, while resistance exercise induces muscle growth. Here we show that the c-Jun N-terminal kinase (JNK) is a molecular switch that when active, stimulates muscle fibers to grow, resulting in increased muscle mass. Conversely, when muscle JNK activation is suppressed, an alternative remodeling program is initiated, resulting in smaller, more oxidative muscle fibers, and enhanced aerobic fitness. When muscle is exposed to mechanical stress, JNK initiates muscle growth via phosphorylation of the transcription factor, SMAD2, at specific linker region residues leading to inhibition of the growth suppressor, myostatin. In human skeletal muscle, this JNK/SMAD signaling axis is activated by resistance exercise, but not endurance exercise. We conclude that JNK acts as a key mediator of muscle remodeling during exercise via regulation of myostatin/SMAD signaling. Endurance and resistance exercise have different effects on skeletal muscle phenotype. Using mouse models and human subjects, the authors show that JNK/Smad2 signaling acts as molecular switch that when activated by resistance exercise leads to hypertrophy, and when inhibited promotes endurance adaptations in muscle.
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DOI：
10.1249/mss.0b013e3181d964e4
发表时间：
2010-10-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Camera, Donny M.;Edge, Johann;Coffey, Vernon G.
通讯作者：
Coffey, Vernon G.
影响因子：
9.3
作者：
Lucarelli, Philippe;Schilling, Marcel;Klingmueller, Ursula
通讯作者：
Klingmueller, Ursula
影响因子：
120.7
作者：
Blair, SN;Kampert, JB;Gibbons, LW
通讯作者：
Gibbons, LW
影响因子：
9.8
作者：
Baar, Keith
通讯作者：
Baar, Keith
影响因子：
16
作者：
Bruning, JC;Michael, MD;Kahn, CR
通讯作者：
Kahn, CR