Polybrominated diphenyl ethers in maternal and fetal blood samples.
Polybrominated diphenyl ethers in maternal and fetal blood samples.
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母体和胎儿血液样本中的多溴二苯基醚。
DOI：
10.1289/ehp.6146
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发表时间：
2003-07
影响因子：
10.4
通讯作者：
Bigsby, RM
中科院分区：
文献类型：
--
作者：
Mazdai, A;Dodder, NG;Abernathy, MP;Hites, RA;Bigsby, RM
多溴联苯醚(PBDEs)被广泛用作塑料、电子、纺织品和建筑材料等消费品的阻燃剂。在人类乳汁、脂肪和血液样本中都发现了多溴二苯醚。啮齿动物研究表明，多溴二苯醚可能会降低血液中甲状腺激素的浓度，从而损害神经发育。在本研究中，我们测定了人胎儿和母体血清中多溴二苯醚和甲状腺激素的浓度。在印第安纳波利斯的印第安纳大学和威沙德纪念县医院分娩的患者年龄超过18岁，被招募参加。采集12份母血和脐带血标本，用气相色谱-质谱法进行分析，用放射免疫法测定甲状腺激素浓度。检测了母体和胎儿血清中6种多溴联苯醚的同系物。孕妇血清中总多溴二苯醚的浓度范围为15~580 ng/g脂肪，胎儿样本中的浓度范围为14~460 ng/g脂肪。单个胎儿的血液浓度与相应的孕妇浓度没有差别，表明测量母亲的多溴二苯醚血液水平有助于预测胎儿暴露；类似地，其他报告显示，母亲乳汁中的多溴二苯醚与胎儿暴露之间存在高度相关性。与其他生物样品的报道一致，四溴联苯醚同系物BDE-47占血清中总多溴联苯醚的53-%。在孕妇和胎儿血清样本中发现的多溴二苯醚浓度是以前在瑞典母亲和婴儿中报道的水平的20-106倍。在这个小样本中，血清多溴二苯醚和甲状腺激素浓度之间没有明显的相关性。我们的研究表明，美国的人类胎儿可能会接触到相对较高水平的多溴二苯醚。需要进一步调查，以确定这些水平是否仅限于印第安纳州中部，并评估这些暴露水平的毒性潜力。
Polybrominated diphenyl ethers (PBDEs) are widely used as flame retardants in consumer goods, such as plastics, electronics, textiles, and construction material. PBDEs have been found in human milk, fat, and blood samples. Rodent studies indicate that PBDEs may be detrimental to neurodevelopment, possibly by lowering thyroid hormone concentrations in blood. In the present study, we determined concentrations of PBDEs and thyroid hormones in human fetal and maternal serum. Patients presenting in labor to Indiana University and Wishard Memorial County hospitals in Indianapolis, who were older than 18 years, were recruited to participate. Twelve paired samples of maternal and cord blood were obtained and analyzed using gas chromatographic mass spectrometry; thyroid hormone concentrations were determined by radioimmunoassay. Six congeners of PBDE were measured in maternal and fetal serum samples. The concentrations of total PBDEs found in maternal sera ranged from 15 to 580 ng/g lipid, and the concentrations found in fetal samples ranged from 14 to 460 ng/g lipid. Individual fetal blood concentrations did not differ from the corresponding maternal concentrations, indicating that measurement of maternal PBDE blood levels is useful in predicting fetal exposure; similarly, other reports have shown a high correlation between PBDE in mother's milk and fetal exposure. In accord with reports on other biologic samples, the tetrabrominated PBDE congener BDE-47 accounted for 53-64% of total PBDEs in the serum. The concentrations of PBDEs found in maternal and fetal serum samples were 20-106-fold higher than the levels reported previously in a similar population of Swedish mothers and infants. In this small sample, there was no apparent correlation between serum PBDEs and thyroid hormone concentrations. Our study shows that human fetuses in the United States may be exposed to relatively high levels of PBDEs. Further investigation is required to determine if these levels are specific to central Indiana and to assess the toxic potential of these exposure levels.
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影响因子：
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