Effects of curcumin on ion channels and transporters.
Effects of curcumin on ion channels and transporters.
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姜黄素对离子通道和转运蛋白的影响
DOI：
10.3389/fphys.2014.00094
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发表时间：
2014
影响因子：
4
通讯作者：
Cai H
中科院分区：
文献类型：
--
作者：
Zhang X;Chen Q;Wang Y;Peng W;Cai H
姜黄素[1，7-双（4-羟基-3-甲氧基苯基）-1，6-庚烯-3，5-二酮]是从姜黄（Curcuma longa）根茎中分离的多酚类化合物，具有抗炎、抗癌、抗氧化、抗动脉粥样硬化、抗微生物和伤口愈合等多种药理活性。姜黄素的这些活性是基于其复杂的分子结构和化学特征，以及其与多种信号分子相互作用的能力。姜黄素调节离子通道和转运蛋白的能力在十年前就被认识到了。囊性纤维化跨膜传导调节因子（CFTR）是姜黄素的离子通道靶点。在研究其抗癌特性的过程中，发现姜黄素抑制ATP结合盒（ABC）家族成员，包括ABCA 1，ABCB 1，ABCC 1和ABCG 2。近年来研究发现，姜黄素对多种通道和转运蛋白有调节作用，如电压门控钾通道（Kv）、高电压门控钙通道（HVGCC）、容量调节阴离子通道（VRAC）、钙释放激活的钙通道（CRAC）、水通道蛋白-4（AQP-4）、葡萄糖转运蛋白等，在这篇综述中，我们的目标是概述姜黄素与不同类型的离子通道和转运蛋白的相互作用，并帮助更好地理解和整合姜黄素多种药理活性的潜在分子机制。
Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione], a polyphenolic compound isolated from the rhizomes of Curcuma longa (turmeric), has been shown to exhibit a wide range of pharmacological activities including anti-inflammatory, anti-cancer, anti-oxidant, anti-atherosclerotic, anti-microbial, and wound healing effects. These activities of curcumin are based on its complex molecular structure and chemical features, as well as its ability to interact with multiple signaling molecules. The ability of curcumin to regulate ion channels and transporters was recognized a decade ago. The cystic fibrosis transmembrane conductance regulator (CFTR) is a well-studied ion channel target of curcumin. During the process of studying its anti-cancer properties, curcumin was found to inhibit ATP-binding cassette (ABC) family members including ABCA1, ABCB1, ABCC1, and ABCG2. Recent studies have revealed that many channels and transporters are modulated by curcumin, such as voltage-gated potassium (Kv) channels, high-voltage-gated Ca2+ channels (HVGCC), volume-regulated anion channel (VRAC), Ca2+ release-activated Ca2+ channel (CRAC), aquaporin-4 (AQP-4), glucose transporters, etc., In this review, we aim to provide an overview of the interactions of curcumin with different types of ion channels and transporters and to help better understand and integrate the underlying molecular mechanisms of the multiple pharmacological activities of curcumin.
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DOI：
10.3390/molecules15031168
发表时间：
2010-03-03
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Duncan RS;Goad DL;Grillo MA;Kaja S;Payne AJ;Koulen P
通讯作者：
Koulen P
DOI：
10.3344/kjp.2012.25.4.221
发表时间：
2012-10
期刊：
The Korean journal of pain
影响因子：
--
作者：
De Paz-Campos MA;Chávez-Piña AE;Ortiz MI;Castañeda-Hernández G
通讯作者：
Castañeda-Hernández G
影响因子：
56.9
作者：
Egan, ME;Pearson, M;Caplan, MJ
通讯作者：
Caplan, MJ
影响因子：
5.8
作者：
Anuchapreeda, S;Leechanachai, P;Limtrakul, P
通讯作者：
Limtrakul, P
影响因子：
4.5
作者：
Feng D;Ohlsson L;Duan RD
通讯作者：
Duan RD