State-dependent architecture of thalamic reticular subnetworks.
State-dependent architecture of thalamic reticular subnetworks.
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DOI：
10.1016/j.cell.2014.06.025
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发表时间：
2014-08-14
期刊：
影响因子：
64.5
通讯作者：
Wilson MA
中科院分区：
文献类型：
--
作者：
Halassa MM;Chen Z;Wimmer RD;Brunetti PM;Zhao S;Zikopoulos B;Wang F;Brown EN;Wilson MA
已知行为状态会影响丘脑和皮层之间的相互作用，这对感觉、行动和认知都很重要。丘脑网状核（TRN）被假定可调节丘脑 - 皮层的传递，但这一过程的潜在功能结构及其状态依赖性尚不清楚。通过将首次丘脑网状核集群记录与心理物理学以及基于连接性的光遗传标记相结合，我们发现丘脑网状核由不同的子网络组成。虽然投向边缘系统的丘脑网状核神经元的活动与觉醒相关，但投向感觉系统的神经元参与纺锤波，并在睡眠期间因慢波而表现出更高的同步性。相反，投向感觉系统的神经元在注意力集中状态下受到抑制，这表明了睡眠和注意力中感觉处理的常见微电路机制。通过对这些丘脑网状核子网络进行光遗传操作，实现了对注意力表现的双向调控。我们的研究结果为不同脑状态下丘脑抑制的差异调节提供了证据，表明丘脑网状核分别控制外部刺激处理和内部产生的计算，这是认知功能的一个基本决定因素。
Behavioral state is known to influence interactions between thalamus and cortex, which are important for sensation, action and cognition. The thalamic reticular nucleus (TRN) is hypothesized to regulate thalamo-cortical transmission, but the underlying functional architecture of this process and its state-dependence are unknown. By combining the first TRN ensemble recording with psychophysics and connectivity-based optogenetic tagging, we find that the TRN is composed of distinct sub-networks. While activity of limbic-projecting TRN neurons correlates with arousal, sensory-projecting neurons participate in spindles and show elevated synchrony by slow waves during sleep. Conversely, sensory-projecting neurons are suppressed by attentional states, demonstrating common microcircuit mechanisms of sensory processing in sleep and attention. Bidirectional manipulation of attentional performance was achieved through optogenetic manipulation of these TRN sub-networks. Our findings provide evidence for differential regulation of thalamic inhibition across brain states, suggesting that the TRN separately controls external stimulus processing and internally-generated computations, a basic determinant of cognitive function.
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DOI：
10.1073/pnas.0504136102
发表时间：
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影响因子：
11.1
作者：
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