Functioning of K channels during sleep.
Functioning of K channels during sleep.
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DOI：
10.1002/arch.21884
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发表时间：
2022-06
影响因子：
2.2
通讯作者：
Kodirov, Sodikdjon A.
中科院分区：
文献类型：
--
作者：
Kodirov, Sodikdjon A.
电压依赖性钾通道(Kv)的功能可能与生物脑的生理状态有关，包括果蝇的睡眠。显然，所有主要类型的钾电流都在该模式生物的中枢神经系统中表达。这些是Shab-Kv2、Shaker-Kv1、Shal-Kv4和Shaw-Kv3ɑ亚基，可以通过膜片钳技术破译。尽管这些通道中的一些可能在睡眠或清醒中起着主导作用，但最近的几项数据并不是决定性的。需要明确的是，由于Kv3和Kv4电流的增加，大型腹侧起搏神经元的动作电位频率在早晨或夜间实际上是较高或较低的。与哺乳动物神经元的结果相比，昆虫的动态钳夹结合电生理学的结果是不可靠的。因为在任何Zeitgeber时间内增加虚拟Kv电导不应显著改变静止膜电位。这篇综述解释了果蝇的睡眠行为基于K电流驱动的动作电位率的神经活动。
The functioning of voltage-dependent K channels (Kv) may correlate with the physiological state of brain in organisms, including the sleep in Drosophila. Apparently, all major types of K currents are expressed in CNS of this model organism. These are the Shab—Kv2, Shaker—Kv1, Shal—Kv4, and Shaw—Kv3 ɑ subunits and can be deciphered by patch-clamp technique. Although it is plausible that some of these channels may play a prevailing role in sleep or wakefulness, several of recent data are not conclusive. It needs to be defined that indeed the frequency of action potentials in large ventral lateral pacemaker neurons is either higher or lower during the morning or night because of an increased Kv3 and Kv4 currents, respectively. The outcomes of dynamic-clamp approach in combination with electrophysiology in insects are unreliable in contrast to those in mammalian neurons. Since the addition of virtual Kv conductance during any Zeitgeber time should not significantly alter the resting membrane potential. This review explains the Drosophila sleep behavior based on neural activity with respect to K current-driven action potential rate.
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影响因子：
3.5
作者：
Ivanov, DV;Tyazhelova, TV;Baranova, AV
通讯作者：
Baranova, AV
影响因子：
2.5
作者：
Sheeba, Vasu;Gu, Huaiyu;Holmes, Todd C.
通讯作者：
Holmes, Todd C.
影响因子：
5.5
作者：
Smith, Philip;Buhl, Edgar;Hodge, James J. L.
通讯作者：
Hodge, James J. L.
DOI：
10.1016/j.cbpa.2011.06.014
发表时间：
2011-10-01
影响因子：
2.3
作者：
Kodirov, Sodikdjon A.
通讯作者：
Kodirov, Sodikdjon A.
DOI：
10.1177/003591576906200916
发表时间：
1969-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY OF MEDICINE-LONDON
影响因子：
--
作者：
OSWALD, I
通讯作者：
OSWALD, I