Comparative genomic analysis of two emergent human adenovirus type 14 respiratory pathogen isolates in China reveals similar yet divergent genomes.
Comparative genomic analysis of two emergent human adenovirus type 14 respiratory pathogen isolates in China reveals similar yet divergent genomes.
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中国两种新出现的人类腺病毒 14 型呼吸道病原体分离株的比较基因组分析揭示了相似但不同的基因组
DOI：
10.1038/emi.2017.78
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发表时间：
2017-11-01
影响因子：
13.2
通讯作者：
Seto D
中科院分区：
文献类型：
--
作者：
Zhang Q;Jing S;Cheng Z;Yu Z;Dehghan S;Shamsaddini A;Yan Y;Li M;Seto D
人类腺病毒14型（HAdV-B14p）最初于1955年在荷兰被确定为急性呼吸道疾病（ARD）病原体。在大约50年的时间里，很少观察到零星的感染。2005年，HAdV-B14p1（一种基因组变体）再次出现，并与美国以及随后的加拿大、英国、爱尔兰和中国的几次大规模ARD暴发有关。该毒株的致死率高于先前报道的该原型和其他hav类型。在中国，HAdV-B14于2010年首次被发现，当时在中国南方（GZ01）和中国北方（BJ430）报告了两例与HAdV-B14无关的ARD病例，随后发生了三次暴发。虽然包括indel分析在内的比较基因组分析显示，具有全基因组数据的三个中国分离株与de Wit原型相似，但都与美国菌株（303600;2007）不同。虽然菌株GZ01和BJ430的基因组几乎相同，但在基因组类型表征和百分比身份上，它们在基因组突变模式上存在微妙的差异。这些基因组表明，HAdV-B14可能有两个谱系，或者是从国外独立引入中国的，或者随后从一个谱系中分化出来；CHN2012可能代表一个单独的子谱系。对中国同时报告的这些新出现毒株的观察有助于了解这些hav病原体的传播、流行病学和演变，并为开发有效的疫苗和公共卫生战略提供基础，包括为预测hav - b14p1可能导致更高死亡率的更大规模疫情而进行全国监测。新兴微生物与感染（2017）6,e92；doi: 10.1038 / emi.2017.78;2017年11月1日在线发布
Human adenovirus type 14 (HAdV-B14p) was originally identified as an acute respiratory disease (ARD) pathogen in The Netherlands in 1955. For approximately fifty years, few sporadic infections were observed. In 2005, HAdV-B14p1, a genomic variant, re-emerged and was associated with several large ARD outbreaks across the U.S. and, subsequently, in Canada, the U.K., Ireland, and China. This strain was associated with an unusually higher fatality rate than previously reported for both this prototype and other HAdV types in general. In China, HAdV-B14 was first observed in 2010, when two unrelated HAdV-B14-associated ARD cases were reported in Southern China (GZ01) and Northern China (BJ430), followed by three subsequent outbreaks. While comparative genomic analysis, including indel analysis, shows that the three China isolates, with whole genome data available, are similar to the de Wit prototype, all are divergent from the U.S. strain (303600; 2007). Although the genomes of strains GZ01 and BJ430 are nearly identical, as per their genome type characterization and percent identities, they are subtly divergent in their genome mutation patterns. These genomes indicate possibly two lineages of HAdV-B14 and independent introductions into China from abroad, or subsequent divergence from one; CHN2012 likely represents a separate sub-lineage. Observations of these simultaneously reported emergent strains in China add to the understanding of the circulation, epidemiology, and evolution of these HAdV pathogens, as well as provide a foundation for developing effective vaccines and public health strategies, including nationwide surveillance in anticipation of larger outbreaks with potentially higher fatality rates associated with HAdV-B14p1.Emerging Microbes & Infections(2017)6,e92; doi:10.1038/emi.2017.78; published online 1 November 2017
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