Epicardial adipose tissue volume as a marker of coronary artery disease severity in patients with diabetes independent of coronary artery calcium: findings from the CTRAD study.
Epicardial adipose tissue volume as a marker of coronary artery disease severity in patients with diabetes independent of coronary artery calcium: findings from the CTRAD study.
复制标题
DOI：
10.1016/j.diabres.2014.08.021
复制
发表时间：
2014-11
影响因子：
5.1
通讯作者：
Malik, Shaista
中科院分区：
文献类型：
--
作者：
Mohar, Dilbahar S.;Salcedo, Jonathan;Hoang, Khiet C.;Kumar, Shivesh;Saremi, Farhood;Erande, Ashwini S.;Naderi, Nassim;Nadeswaran, Pradeep;Le, Christine;Malik, Shaista
关键词：
在2型糖尿病（DM-2）患者中，使用心脏计算机断层扫描血管造影（CTA）评价心外膜脂肪组织（EAT）体积与冠状动脉疾病（CAD）严重程度之间的相关性，独立于传统风险因素和冠状动脉钙化（CAC）评分。在计算CTRAD研究中92例DM-II患者的EAT体积、CAD严重程度和钙评分后，采用多变量分析评估独立相关性。我们将CAD严重程度分为无（正常冠状动脉）、轻中度（狭窄<70%）和重度（狭窄≥ 70%）。共有39例（42.3%）无症状糖尿病患者没有CAD; 30.4%有轻度/中度CAD; 27.1%有重度CAD。与轻度/中度CAD（112.7 cm 3）和无CAD（107.5 cm 3）相比，重度CAD患者的平均EAT体积最高（143.14 cm 3）（p= 0.003）。校正临床危险因素后，特别是CAC评分，多变量回归分析显示EAT体积是该样本中CAD严重程度的独立预测因子（比值比11.2，95%置信区间1.7 - 73.8，p =0.01）。无症状DM-II患者EAT量增加与严重CAD的存在相关，与BMI和CAC以及传统风险因素无关。
The association between epicardial adipose tissue (EAT) volume and coronary artery disease (CAD) severity was evaluated, independent of traditional risk factors and coronary artery calcium (CAC) scores, in patients with diabetes type 2 (DM-2) using cardiac computed tomography angiography (CTA). A multivariate analysis was utilized to assess for an independent association after calculating EAT volume, CAD severity, and calcium scores in 92 patients with DM-II from the CTRAD study. We graded CAD severity as none (normal coronaries), mild-moderate (<70% stenosis), and severe (70% or greater stenosis). A total of 39 (42.3 %) asymptomatic patients with diabetes did not have CAD; 30.4% had mild/moderate CAD; and 27.1% had severe CAD. Mean EAT volume was highest in patients with severe CAD (143.14 cm3) as compared to mild/moderate CAD (112.7 cm3), and no CAD (107.5 cm3) (p= 0.003). After adjustment of clinical risk factors, notably, CAC score, multivariate regression analysis showed EAT volume was an independent predictor of CAD severity in this sample (odds ratio 11.2, 95% confidence interval 1.7 –73.8, p =0.01). Increasing EAT volume in asymptomatic patients with DM-II is associated with presence of severe CAD, independent of BMI and CAC, as well as traditional risk factors.
登录
查看更多内容
DOI：
10.1038/oby.2003.45
发表时间：
2003-02-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Iacobellis, G;Assael, F;Leonetti, F
通讯作者：
Leonetti, F
影响因子：
9.3
作者：
Kim, Hyun Min;Kim, Kwang Joon;Kim, Young Jin
通讯作者：
Kim, Young Jin
影响因子：
5.3
作者：
Gorter, Petra M.;van Lindert, Anne S. R.;Visseren, Frank L. J.
通讯作者：
Visseren, Frank L. J.
影响因子：
7.1
作者：
BAUMGARTNER, RN;HEYMSFIELD, SB;BERNARDINO, M
通讯作者：
BERNARDINO, M
影响因子：
24
作者：
Coutinho, Thais;Goel, Kashish;Lopez-Jimenez, Francisco
通讯作者：
Lopez-Jimenez, Francisco