Stroke outcome in the ketogenic state--a systematic review of the animal data.

Stroke outcome in the ketogenic state--a systematic review of the animal data.
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DOI:
10.1111/j.1471-4159.2012.07943.x
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发表时间:
2012-11
影响因子:
4.7
通讯作者:
Murphy SP
Murphy SP
中科院分区:
医学2区
文献类型:
--
作者:
Gibson CL;Murphy AN;Murphy SP

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As a predictor of potential clinical outcome, we performed a systematic review of controlled studies that assessed experimental stroke outcome in rodents maintained on special diets (calorie restriction, ketogenic diet) or following the direct administration of ketone bodies. Pre-clinical studies were identified by searching web databases and the reference lists of relevant original articles and reviews. Sixteen published studies (a total of 733 experimental animals) met specific criteria and were analyzed using Cochrane Review Manager software. This resulted in objective evidence to suggest beneficial effects of the ketogenic pathway on pathologic and functional outcomes following experimental stroke.
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