Computational simulation of hematocrit effects on arterial gas embolism dynamics.
Computational simulation of hematocrit effects on arterial gas embolism dynamics.
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DOI：
10.3357/asem.3085.2012
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发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Eckmann DM
中科院分区：
文献类型：
--
作者：
Mukundakrishnan K;Ayyaswamy PS;Eckmann DM
最近的计算研究揭示了在动脉气体栓塞中可能导致内皮细胞（EC）损伤的各种流体动力学机制。最近的其他研究表明，红细胞压积水平的变化可能在确定减压病与气体栓塞相关的神经系统并发症的严重程度方面起重要作用。为了形成一个全面的图像，我们计算模拟了红细胞压积变化对不同大小的动脉血管中几乎闭塞的气泡运动的影响。计算方法采用轴对称有限差分浸入边界数值法精确跟踪界面的气泡动力学。红细胞压积的变化范围在0.2-0.6之间。所选择的血管大小对应于正常人的小动脉、小动脉和大动脉。相关的流体动力学相互作用之间的气泡和ec内衬血管管腔已被表征和量化为红细胞压积水平的功能。特别是，剪切应力的变化、时空剪切应力梯度以及气泡和血管内皮表面之间的间隙对EC损伤的影响已经计算出来。结果表明，在小动脉中，随着血细胞比容水平的增加，气体栓塞对ec细胞壁的有害流体动力学效应显著增强。然而，在小动脉中没有观察到这种明显的红细胞压积水平变化。
Recent computational investigations have shed light into the various hydrodynamic mechanisms at play during arterial gas embolism that may result in endothelial cell (EC) injury. Other recent studies have suggested that variations in hematocrit level may play an important role in determining the severity of neurological complications due to decompression sickness associated with gas embolism. Towards developing a comprehensive picture, we have computationally modeled the effect of hematocrit variations on the motion of a nearly occluding gas bubble in arterial blood vessels of various sizes. The computational methodology is based on an axisymmetric finite difference immersed boundary numerical method to precisely track the blood-bubble dynamics of the interface. Hematocrit variations are taken to be in the range 0.2–0.6. The chosen blood vessel sizes correspond to small arteries, and small and large arterioles in normal humans. Relevant hydrodynamic interactions between the gas bubble and EC-lined vessel lumen have been characterized and quantified as a function of hematocrit levels. In particular, the variations in shear stress, spatial and temporal shear stress gradients, and the gap between bubble and vascular endothelium surfaces that contribute to EC injury have been computed. The results suggest that in small arteries, the deleterious hydrodynamic effects of the gas embolism on EC-lined cell wall are significantly amplified as the hematocrit levels increase. However, such pronounced variations with hematocrit levels are not observed in the arterioles.
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影响因子：
18.4
作者：
Gempp, E.;Blatteau, J. E.;Louge, P.
通讯作者：
Louge, P.
影响因子：
2.5
作者：
Boussuges, A;Blanc, P;Sainty, JM
通讯作者：
Sainty, JM
DOI：
10.1115/1.3153310
发表时间：
2009-07-01
影响因子：
1.7
作者：
Mukundakrishnan, K.;Ayyaswamy, P. S.;Eckmann, D. M.
通讯作者：
Eckmann, D. M.
影响因子：
3.3
作者：
Dailey, H. L.;Ricles, L. M.;Ghadiali, S. N.
通讯作者：
Ghadiali, S. N.
影响因子：
8.8
作者：
Eckmann, DM;Diamond, SL
通讯作者：
Diamond, SL