The CRYPTOCHROME photoreceptor gates PDF neuropeptide signaling to set circadian network hierarchy in Drosophila.
The CRYPTOCHROME photoreceptor gates PDF neuropeptide signaling to set circadian network hierarchy in Drosophila.
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DOI：
10.1016/j.cub.2009.10.058
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发表时间：
2009-12-15
期刊：
影响因子：
--
通讯作者：
Allada R
中科院分区：
文献类型：
--
作者：
Zhang L;Lear BC;Seluzicki A;Allada R
Circadian clocks in the brain are organized as coupled oscillators that integrate seasonal cues to time daily behaviors. In Drosophila, the PIGMENT DISPERSING FACTOR (PDF) neuropeptide expressing morning (M) and non-PDF evening (E) cells are coupled cell groups important for morning and evening behavior, respectively. Depending on day length, either M- (short days) or E-cells (long days) dictate both morning and evening phase, a phenomenon we term network hierarchy. To examine the role of PDF in light-dark conditions, we examined flies lacking both the PDF receptor (PDFR) and the circadian photoreceptor CRYPTOCHROME (CRY). We found that subsets of E-cells exhibit molecular oscillations antiphase to those of wild-type flies, single cry mutants, or single Pdfr mutants, demonstrating a potent role for PDF in light-mediated entrainment specifically in the absence of CRY. Moreover, evening behavioral phase is more strongly reset by PDF(+) M-cells in the absence of CRY. Based on our findings, we propose that CRY can gate PDF signaling to determine behavioral phase and network hierarchy.
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