Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1.
Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1.
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DOI：
10.1093/plphys/kiac480
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发表时间：
2023-01-02
期刊：
影响因子：
7.4
通讯作者：
Lapin, Dmitry
中科院分区：
文献类型：
--
作者：
Johanndrees, Oliver;Baggs, Erin L.;Uhlmann, Charles;Locci, Federica;Laessle, Henriette L.;Melkonian, Katharina;Kaeufer, Kiara;Dongus, Joram A.;Nakagami, Hirofumi;Krasileva, Ksenia, V;Parker, Jane E.;Lapin, Dmitry
Toll/白细胞介素-1受体（TIR）结构域是所有界域免疫系统的组成部分。在植物中，TIR存在于核苷酸结合的富含亮氨酸重复序列（NLR）免疫受体、NLR样蛋白和仅TIR蛋白中。尽管植物中的TIR-NLR和TIR信号传导需要增强的疾病易感性1（EDS 1）蛋白家族，但TIR在没有EDS 1成员的物种中持续存在。为了评估特定TIR组是否与EDS 1一起进化，我们搜索了TIR-EDS 1共现模式。通过对39种藻类和陆生植物的TIR结构域进行大规模系统发育分析，我们确定了4个TIR家族，这些家族由几个植物目共享。一组发生在真双子叶植物的TIR-NLR中，另一组发生在真双子叶植物和木兰科植物的TIR-NLR中。另外两个群体分布更广。一个保守的仅TIR组与EDS 1共存，该组的成员引起EDS 1依赖性细胞死亡。与此相反，玉米（玉米）代表TIR蛋白与tetratricopeptide重复也存在于物种没有EDS 1和诱导EDS 1独立的细胞死亡。我们的数据提供了一个基于遗传学的植物TIR分类，并确定了似乎与EDS 1一起进化并依赖于EDS 1的TIR，而其他TIR具有EDS 1独立的活性。植物Toll/白细胞介素-1受体结构域蛋白可以利用不同的机制诱导细胞死亡。
Toll/Interleukin-1 receptor (TIR) domains are integral to immune systems across all kingdoms. In plants, TIRs are present in nucleotide-binding leucine-rich repeat (NLR) immune receptors, NLR-like, and TIR-only proteins. Although TIR-NLR and TIR signaling in plants require the ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) protein family, TIRs persist in species that have no EDS1 members. To assess whether particular TIR groups evolved with EDS1, we searched for TIR-EDS1 co-occurrence patterns. Using a large-scale phylogenetic analysis of TIR domains from 39 algal and land plant species, we identified 4 TIR families that are shared by several plant orders. One group occurred in TIR-NLRs of eudicots and another in TIR-NLRs across eudicots and magnoliids. Two further groups were more widespread. A conserved TIR-only group co-occurred with EDS1 and members of this group elicit EDS1-dependent cell death. In contrast, a maize (Zea mays) representative of TIR proteins with tetratricopeptide repeats was also present in species without EDS1 and induced EDS1-independent cell death. Our data provide a phylogeny-based plant TIR classification and identify TIRs that appear to have evolved with and are dependent on EDS1, while others have EDS1-independent activity. Plant Toll/Interleukin-1 receptor domain proteins can use different mechanisms to induce cell death.
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影响因子：
16.6
作者：
Bhandari, Deepak D.;Lapin, Dmitry;Parker, Jane E.
通讯作者：
Parker, Jane E.
影响因子：
4.6
作者：
Anthoney, Niki;Foldi, Istvan;Hidalgo, Alicia
通讯作者：
Hidalgo, Alicia
影响因子：
16.2
作者：
Essuman K;Summers DW;Sasaki Y;Mao X;DiAntonio A;Milbrandt J
通讯作者：
Milbrandt J
影响因子：
5.6
作者：
Adlung N;Prochaska H;Thieme S;Banik A;Blüher D;John P;Nagel O;Schulze S;Gantner J;Delker C;Stuttmann J;Bonas U
通讯作者：
Bonas U
影响因子：
82.9
作者：
Cirl, Christine;Wieser, Andreas;Miethke, Thomas
通讯作者：
Miethke, Thomas