On the transition from reconsolidation to extinction of contextual fear memories.
On the transition from reconsolidation to extinction of contextual fear memories.
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DOI：
10.1101/lm.045724.117
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Lee JLC
中科院分区：
文献类型：
--
作者：
Cassini LF;Flavell CR;Amaral OB;Lee JLC
联想记忆的提取可以导致不同的现象。短暂的再暴露期往往会触发再巩固，而更长时间的再暴露期则会触发消退。在欲望和恐惧线索的巴甫洛夫记忆中，观察到一个中间的“零点”时期，在那里两个过程似乎都没有参与。在这里，我们调查了这种现象是否延伸到上下文恐惧记忆。成年大鼠接受情境恐惧条件化范式，2 d后再次暴露于情境3、5、10、20或30 min，再次暴露后立即注射MK-801或生理盐水，并在第二天进行测试。我们观察到MK-801在3分钟和30分钟的疗程中分别对再巩固和消退有显著影响。然而，它没有显着的影响，5分钟，10分钟，或20分钟的会议，即使冻结减少从重新暴露到测试。进一步的分析表明，这不太可能是由于人口水平的转变点可变造成的。总之，结果表明，在上下文的恐惧记忆有一个真正的“零点”之间的参数，诱导再巩固和灭绝，所定义的MK-801的影响，虽然NMDA受体独立的减少冻结仍然可以发生在这些条件下。
Retrieval of an associative memory can lead to different phenomena. Brief reexposure sessions tend to trigger reconsolidation, whereas more extended ones trigger extinction. In appetitive and fear cued Pavlovian memories, an intermediate “null point” period has been observed where neither process seems to be engaged. Here we investigated whether this phenomenon extends to contextual fear memory. Adult rats were subjected to a contextual fear conditioning paradigm, reexposed to the context 2 d later for 3, 5, 10, 20, or 30 min, with immediate injections of MK-801 or saline following reexposure, and tested on the following day. We observed a significant effect of MK-801 with the 3- and 30-min sessions, impairing reconsolidation and extinction, respectively. However, it did not have significant effects with 5-, 10-, or 20-min sessions, even though freezing decreased from reexposure to test. Further analyses indicated that this is not likely to be due to a variable transition point at the population level. In conclusion, the results show that in contextual fear memories there is a genuine “null point” between the parameters that induce reconsolidation and extinction, as defined by the effects of MK-801, although NMDA receptor-independent decreases in freezing can still occur in these conditions.
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DOI：
10.1101/lm.038513.115
发表时间：
2015-08
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Alfei JM;Ferrer Monti RI;Molina VA;Bueno AM;Urcelay GP
通讯作者：
Urcelay GP
影响因子：
9.2
作者：
Diaz-Mataix, Lorenzo;Ruiz Martinez, Raquel Chacon;Schafe, Glenn E.;LeDoux, Joseph E.;Doyere, Valerie
通讯作者：
Doyere, Valerie
影响因子：
56.9
作者：
Eisenberg, M;Kobilo, T;Dudai, Y
通讯作者：
Dudai, Y
影响因子：
2.7
作者：
Brabant, Christian;Charlier, Yana;Tirelli, Ezio
通讯作者：
Tirelli, Ezio
影响因子：
5.3
作者：
de la Fuente, Veronica;Freudenthal, Ramiro;Romano, Arturo
通讯作者：
Romano, Arturo