Effects of sleep on memory for conditioned fear and fear extinction.
Effects of sleep on memory for conditioned fear and fear extinction.
复制标题
DOI：
10.1037/bul0000014
复制
发表时间：
2015-07
影响因子：
22.4
通讯作者：
Milad, Mohammed R.
中科院分区：
文献类型：
--
作者：
Pace-Schott, Edward F.;Germain, Anne;Milad, Mohammed R.
延长有条件的恐惧的记忆是控制睡眠的基本哺乳动物机制。将被检查。在恐惧和延伸的记忆中，在慢波睡眠过程中进行了相同的边缘结构，这可能会进行延长。扩展记忆可以通过加强策略性的睡眠来改善焦虑症。
Learning and memory for extinction of conditioned fear is a basic mammalian mechanism for regulating negative emotion. Sleep promotes both the consolidation of memory and the regulation of emotion. Sleep can influence consolidation and modification of memories associated with both fear and its extinction. After brief overviews of the behavior and neural circuitry associated with fear conditioning, extinction learning and extinction memory in the rodent and human, interactions of sleep with these processes will be examined. Animal and human studies suggest that sleep can serve to consolidate both fear and extinction memory. In humans, sleep also promotes generalization of extinction memory. Time-of-day effects on extinction learning and generalization are also seen. REM may be a sleep stage of particular importance for the consolidation of both fear and extinction memory as evidenced by selective REM deprivation experiments. REM sleep is accompanied by selective activation of the same limbic structures implicated in the learning and memory of fear and extinction. Preliminary evidence also suggests extinction learning can take place during slow wave sleep. Study of low-level processes such as conditioning, extinction and habituation may allow sleep effects on emotional memory to be identified and inform study of sleep’s effects on more complex, emotionally salient declarative memories. Anxiety disorders are marked by impairments of both sleep and extinction memory. Improving sleep quality may ameliorate anxiety disorders by strengthening naturally acquired extinction. Strategically timed sleep may be used to enhance treatment of anxiety by strengthening therapeutic extinction learned via exposure therapy.
登录
查看更多内容
从分子到全脑网络的睡眠，可塑性和记忆力。
影响因子：
9.2
作者：
Abel, Ted;Havekes, Robbert;Saletin, Jared M.;Walker, Matthew P.
通讯作者：
Walker, Matthew P.
影响因子：
10.3
作者：
Babson, Kimberly A.;Feldner, Matthew T.
通讯作者：
Feldner, Matthew T.
影响因子：
2.9
作者：
Corley, Michael J.;Caruso, Michael J.;Takahashi, Lorey K.
通讯作者：
Takahashi, Lorey K.
影响因子：
10.6
作者：
Breslau, N;Roth, T;Andreski, P
通讯作者：
Andreski, P
影响因子：
4.1
作者：
Blechert, Jens;Michael, Tanja;Wilhelm, Frank H.
通讯作者：
Wilhelm, Frank H.