Engineering Tissue-Informed Biomaterials to Advance Pulmonary Regenerative Medicine.
Engineering Tissue-Informed Biomaterials to Advance Pulmonary Regenerative Medicine.
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工程组织信息生物材料以促进肺部再生医学。
DOI：
10.3389/fmed.2021.647834
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发表时间：
2021
影响因子：
3.9
通讯作者：
Magin CM
中科院分区：
文献类型：
--
作者：
Campbell DR Jr;Senger CN;Ryan AL;Magin CM
特意设计用于支持诱导多能干细胞（iPSCs）扩增、分化和三维（3D）培养的生物材料可能为慢性呼吸系统疾病的细胞疗法铺平道路。全球数百万人患有这些疾病，它们是发病和死亡的重要原因。目前，对于大多数晚期肺部疾病没有有效的治疗方法，肺移植仍然是许多慢性病患者的唯一希望。关键意见领袖推测，新型冠状病毒（COVID - 19）可能导致长期肺部损伤，进一步加剧了对再生疗法的需求。基于再生细胞疗法的新策略利用人类iPSCs的分化能力来研究肺部疾病的发病机制和治疗方法。令人兴奋的是，生物材料是一个可以精确设计以引导干细胞分化的细胞培养平台。在此，我们更深入地审视肺部工程中iPSC分化的最新技术水平，提供支持生物材料提高干细胞分化能力的证据，并讨论我们对组织信息性生物材料改变肺部再生医学潜力的观点。
Biomaterials intentionally designed to support the expansion, differentiation, and three-dimensional (3D) culture of induced-pluripotent stem cells (iPSCs) may pave the way to cell-based therapies for chronic respiratory diseases. These conditions are endured by millions of people worldwide and represent a significant cause of morbidity and mortality. Currently, there are no effective treatments for the majority of advanced lung diseases and lung transplantation remains the only hope for many chronically ill patients. Key opinion leaders speculate that the novel coronavirus, COVID-19, may lead to long-term lung damage, further exacerbating the need for regenerative therapies. New strategies for regenerative cell-based therapies harness the differentiation capability of human iPSCs for studying pulmonary disease pathogenesis and treatment. Excitingly, biomaterials are a cell culture platform that can be precisely designed to direct stem cell differentiation. Here, we present a closer look at the state-of-the-art of iPSC differentiation for pulmonary engineering, offer evidence supporting the power of biomaterials to improve stem cell differentiation, and discuss our perspective on the potential for tissue-informed biomaterials to transform pulmonary regenerative medicine.
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影响因子：
6.1
作者：
Doherty, GM;Christie, SN;Heaney, LG
通讯作者：
Heaney, LG
影响因子：
7.7
作者：
Dye BR;Hill DR;Ferguson MA;Tsai YH;Nagy MS;Dyal R;Wells JM;Mayhew CN;Nattiv R;Klein OD;White ES;Deutsch GH;Spence JR
通讯作者：
Spence JR
影响因子：
4.6
作者：
Goetzke, Roman;Keijdener, Hans;Wagner, Wolfgang
通讯作者：
Wagner, Wolfgang
影响因子：
4.1
作者：
Davis-Hall, Duncan;Vy Nguyen;Magin, Chelsea M.
通讯作者：
Magin, Chelsea M.
DOI：
10.1007/978-1-62703-125-7_10
发表时间：
2013
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Gonzalez, Robert F;Dobbs, Leland G
通讯作者：
Dobbs, Leland G