Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes.
Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes.
复制标题
Stat3 缺陷 T 淋巴细胞中 IL-2 介导的 IL-2 受体 α 链表达缺陷。
作者：
H. Akaishi;K. Takeda;T. Kaisho;R. Shineha;S. Satomi;J. Takeda;S. Akira
Stat3 是信号转导子和转录激活子 (STAT) 的成员，可被多种细胞因子激活。最近，已经产生了 T 细胞中特异性缺乏 Stat3 的小鼠，并且由于 IL-6 介导的细胞凋亡预防受损而显示出在 IL-6 诱导的增殖中存在缺陷。在本研究中，我们发现 Stat3 缺陷的 T 细胞在 IL-2 诱导的增殖中存在部分缺陷。 Stat3 缺陷的 T 细胞表现出 IL-2 介导的 IL-2 受体 (IL-2R) α 链表达受损。当用高剂量 IL-2 刺激 Stat3 缺陷型 T 细胞时，这些 T 细胞表达 IL-2Rα 并增殖至与野生型 T 细胞相似的程度。这些表明 Stat3 激活是 IL-2 通过 IL-2Rα 诱导有效 T 细胞增殖所必需的。总而言之，这些发现表明 T 细胞中 Stat3 的激活通过不同的机制负责 IL-2 和 IL-6 诱导的增殖。
Stat3, a member of signal transducers and activators of transcription (STAT), is activated by a variety of cytokines. Recently, mice lacking Stat3 specifically in T cells have been generated and shown to be defective in IL-6-induced proliferation due to the impairment in IL-6-mediated prevention of apoptosis. In the present study, we show that Stat3-deficient T cells are partially defective in IL-2-induced proliferation. Stat3-deficient T cells show impaired IL-2-mediated IL-2 receptor (IL-2R) alpha chain expression. When Stat3-deficient T cells are stimulated with high-dose IL-2, these T cells express IL-2Ralpha and proliferate to similar extents as wild-type T cells. These demonstrate that Stat3 activation is required for efficient T cell proliferation by IL-2 through IL-2Ralpha induction. Taken together, these findings demonstrate that Stat3 activation in T cells is responsible for IL-2- and IL-6-induced proliferation through distinct mechanisms.
影响因子：
56.9
作者：
Darnell, JE
通讯作者：
Darnell, JE
影响因子：
56.9
作者：
ZHONG, Z;WEN, ZL;DARNELL, JE
通讯作者：
DARNELL, JE