Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study.
Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study.
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DOI：
10.1016/j.jpain.2011.08.005
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发表时间：
2011-11
期刊：
影响因子：
--
通讯作者：
Diatchenko L
中科院分区：
文献类型：
--
作者：
Smith SB;Maixner DW;Greenspan JD;Dubner R;Fillingim RB;Ohrbach R;Knott C;Slade GD;Bair E;Gibson DG;Zaykin DV;Weir BS;Maixner W;Diatchenko L
遗传因素在持续性疼痛病症的病因学中起作用，通过调节潜在过程如伤害性敏感性、心理健康、炎症和自主反应来调节疼痛。然而，迄今为止，只有少数基因与颞下颌关节紊乱病（TMD）有关。本研究评估了358个参与疼痛过程的基因，比较了OPPERA（口面疼痛：前瞻性评价和风险评估）研究合作协议中166例慢性TMD患者和1442例对照者的等位基因频率。为了提高统计能力，182例TMD病例和170例对照从一个类似的研究纳入分析。使用Pain Research Panel进行基因分型，这是一种代表3295个单核苷酸多态性的Affyssin基因芯片，包括用于调整人群分层的祖先信息标记。调整后的遗传标记和TMD病例状态之间的关联进行了评估，使用逻辑回归。OPPERA的研究结果提供了证据支持先前报道的TMD与两个基因之间的关联：HTR2A和COMT。其他基因被发现是TMD的潜在新遗传风险因素，包括NR3C1，CAMK 4，CHRM 2，IFRD 1和GRK 5。虽然这些发现需要在独立的队列中重复，但这些基因可能代表了TMD风险的重要标志物，并确定了治疗干预的潜在靶点。
Genetic factors play a role in the etiology of persistent pain conditions, putatively by modulating underlying processes such as nociceptive sensitivity, psychological well-being, inflammation, and autonomic response. However, to date, only a few genes have been associated with temporomandibular disorders (TMD). This study evaluated 358 genes involved in pain processes, comparing allelic frequencies between 166 cases with chronic TMD and 1442 controls enrolled in the OPPERA (Orofacial Pain: Prospective Evaluation and Risk Assessment) study cooperative agreement. To enhance statistical power, 182 TMD cases and 170 controls from a similar study were included in the analysis. Genotyping was performed using the Pain Research Panel, an Affymetrix gene chip representing 3295 single nucleotide polymorphisms, including ancestry-informative markers that were used to adjust for population stratification. Adjusted associations between genetic markers and TMD case status were evaluated using logistic regression. The OPPERA findings provided evidence supporting previously-reported associations between TMD and two genes: HTR2A and COMT. Other genes were revealed as potential new genetic risk factors for TMD, including NR3C1, CAMK4, CHRM2, IFRD1, and GRK5. While these findings need to be replicated in independent cohorts, the genes potentially represent important markers of risk for TMD and they identify potential targets for therapeutic intervention.
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影响因子：
3.5
作者：
Diatchenko, L;Slade, GD;Maixner, W
通讯作者：
Maixner, W
DOI：
10.1016/j.jpain.2009.04.001
发表时间：
2009-07
期刊：
The journal of pain
影响因子：
--
作者：
Kim H;Clark D;Dionne RA
通讯作者：
Dionne RA
影响因子：
5
作者：
LARSSON, B;BILLE, B;PEDERSEN, NL
通讯作者：
PEDERSEN, NL
影响因子：
5.5
作者：
Fejer, R;Hartvigsen, J;Kyvik, KO
通讯作者：
Kyvik, KO
影响因子：
8.8
作者：
Belfer, I;Wu, TX;Max, MB
通讯作者：
Max, MB