Cross-continental experimental infections reveal distinct defence mechanisms in populations of the three-spined stickleback Gasterosteus aculeatus.
Cross-continental experimental infections reveal distinct defence mechanisms in populations of the three-spined stickleback Gasterosteus aculeatus.
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DOI：
10.1098/rspb.2021.1758
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发表时间：
2021-09-29
期刊：
影响因子：
--
通讯作者：
Kalbe M
中科院分区：
文献类型：
--
作者：
Piecyk A;Hahn MA;Roth O;Dheilly NM;Heins DC;Bell MA;Kalbe M
宿主-寄生虫关联的流行病学特征取决于宿主、寄生虫及其相互作用的影响。寄生虫进化出感染和利用宿主的机制，而宿主进化出预防感染和限制有害影响的机制。这些特征在不同人群中存在差异的原因和方式仍不清楚。通过对来自阿拉斯加和欧洲种群的三刺刺鱼 Gasterosteus aculeatus 及其物种特异性绦虫寄生虫 Schistocephalus Solidus 进行实验交叉感染，我们解开了宿主、寄生虫以及不同地理尺度上流行病学特征的相互作用的影响。我们假设宿主和寄生虫的主效应将在大陆内部和大陆之间占主导地位，尽管相互作用效应将显示大陆内部和大陆之间自然选择的地理差异。我们发现，预防感染的机制（定性抵抗）仅发生在来自不同大陆的宿主和寄生虫的组合中，而限制寄生虫负担（定量抵抗）和减少感染的有害影响（耐受性）的机制则针对宿主群体。我们得出的结论是，进化有利于不同地理范围内的不同防御机制，并且在大型寄生虫感染的研究中区分定性抗性、定量抗性和耐受性的概念非常重要。
Epidemiological traits of host–parasite associations depend on the effects of the host, the parasite and their interaction. Parasites evolve mechanisms to infect and exploit their hosts, whereas hosts evolve mechanisms to prevent infection and limit detrimental effects. The reasons why and how these traits differ across populations still remain unclear. Using experimental cross-infection of three-spined stickleback Gasterosteus aculeatus and their species-specific cestode parasites Schistocephalus solidus from Alaskan and European populations, we disentangled host, parasite and interaction effects on epidemiological traits at different geographical scales. We hypothesized that host and parasite main effects would dominate both within and across continents, although interaction effects would show geographical variation of natural selection within and across continents. We found that mechanisms preventing infection (qualitative resistance) occurred only in a combination of hosts and parasites from different continents, while mechanisms limiting parasite burden (quantitative resistance) and reducing detrimental effects of infection (tolerance) were host-population specific. We conclude that evolution favours distinct defence mechanisms on different geographical scales and that it is important to distinguish concepts of qualitative resistance, quantitative resistance and tolerance in studies of macroparasite infections.
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影响因子：
1.9
作者：
FRISCHKNECHT, M
通讯作者：
FRISCHKNECHT, M
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
DOI：
10.1111/j.1095-8312.2012.01907.x
发表时间：
2012-08-01
影响因子：
1.9
作者：
Heins, David C.
通讯作者：
Heins, David C.
影响因子：
3.3
作者：
Duncan, Alison B.;Fellous, Simon;Kaltz, Oliver
通讯作者：
Kaltz, Oliver
影响因子：
4.8
作者：
Benesh, Daniel P.;Kalbe, Martin
通讯作者：
Kalbe, Martin