Recent Developments in Mycobacteria-Based Live Attenuated Vaccine Candidates for Tuberculosis.
Recent Developments in Mycobacteria-Based Live Attenuated Vaccine Candidates for Tuberculosis.
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DOI：
10.3390/biomedicines10112749
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发表时间：
2022-10-29
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
接种疫苗是刺激宿主免疫反应和降低人类对微生物感染(如结核病)的发病率和死亡率的一种极好的方法。卡介苗(BCG)是世界上应用最广泛的疫苗，也是世界卫生组织(WHO)批准的唯一预防结核病的疫苗。尽管卡介苗为儿童提供了“保护性”免疫，防止结核分枝杆菌(Mtb)感染发展为活动性结核病，但这种疫苗在保护具有活动性结核病表现的成年人方面无效，例如多重耐药、广泛耐药和完全耐药(MDR/XDR/TDR)病例，以及结核病与免疫损害健康状况的共存，如艾滋病毒感染或糖尿病。此外，卡介苗可能会导致感染艾滋病毒或其他免疫功能受损的人患病。由于卡介苗的这些局限性，迫切需要新的战略来改进全球结核病控制措施。由于活疫苗可引起更广泛的免疫反应，且不需要佐剂，因此开发重组卡介苗(RBCG)候选疫苗作为目前批准的预防结核病的卡介苗的潜在替代品受到了极大的关注。在这份报告中，我们旨在介绍我们认为值得研究的关于基于分枝杆菌的新型减毒活结核病疫苗候选的最新发现和悬而未决的问题。我们还具体讨论了与结核病疫苗测试相关的两个关键动物模型--小鼠和兔的重要特征。我们的综述强调，阻止结核分枝杆菌潜伏感染(LTBI)重新激活为活动性结核病的疫苗的开发将对减少结核分枝杆菌的传播和传播产生重大影响。这里讨论的结果和想法仅基于过去五年的报告，以保持对最近事态发展的关注。
Vaccination is an excellent approach to stimulating the host immune response and reducing human morbidity and mortality against microbial infections, such as tuberculosis (TB). Bacillus Calmette–Guerin (BCG) is the most widely administered vaccine in the world and the only vaccine approved by the World Health Organization (WHO) to protect against TB. Although BCG confers “protective” immunity in children against the progression of Mycobacterium tuberculosis (Mtb) infection into active TB, this vaccine is ineffective in protecting adults with active TB manifestations, such as multiple-, extensive-, and total-drug-resistant (MDR/XDR/TDR) cases and the co-existence of TB with immune-compromising health conditions, such as HIV infection or diabetes. Moreover, BCG can cause disease in individuals with HIV infection or other immune compromises. Due to these limitations of BCG, novel strategies are urgently needed to improve global TB control measures. Since live vaccines elicit a broader immune response and do not require an adjuvant, developing recombinant BCG (rBCG) vaccine candidates have received significant attention as a potential replacement for the currently approved BCG vaccine for TB prevention. In this report, we aim to present the latest findings and outstanding questions that we consider worth investigating regarding novel mycobacteria-based live attenuated TB vaccine candidates. We also specifically discuss the important features of two key animal models, mice and rabbits, that are relevant to TB vaccine testing. Our review emphasizes that the development of vaccines that block the reactivation of latent Mtb infection (LTBI) into active TB would have a significant impact in reducing the spread and transmission of Mtb. The results and ideas discussed here are only based on reports from the last five years to keep the focus on recent developments.
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影响因子：
3.7
作者：
Magalhaes, Isabelle;Sizemore, Donata R.;Ahmed, Raija K.;Mueller, Stefanie;Wehlin, Lena;Scanga, Charles;Weichold, Frank;Schirru, Giulia;Pau, Maria Grazia;Goudsmit, Jaap;Kuhlmann-Berenzon, Sharon;Spangberg, Mats;Andersson, Jan;Gaines, Hans;Thorstensson, Rigmor;Skeiky, Yasir A. W.;Sadoff, Jerry;Maeurer, Markus
通讯作者：
Maeurer, Markus
影响因子：
4.6
作者：
Gunasena, Manuja;Shukla, Rajni Kant;Yao, Naiquan;Mejia, Oscar Rosas;Powell, Michael D.;Oestreich, Kenneth J.;de Jesus Aceves-Sanchez, Michel;Alberto Flores-Valdez, Mario;Liyanage, Namal P. M.;Robinson, Richard T.
通讯作者：
Robinson, Richard T.
影响因子：
3.2
作者：
Flores-Valdez, Mario Alberto;Schoolnik, Gary K.
通讯作者：
Schoolnik, Gary K.
DOI：
10.1007/978-1-0716-1884-4_20
发表时间：
2022-01-01
期刊：
VACCINE DESIGN, VOL. 1, 2 EDITION
影响因子：
--
作者：
Gopalaswamy, Radha;Subbian, Selvakumar
通讯作者：
Subbian, Selvakumar
影响因子：
1
作者：
Akkina, Ramesh;Barber, Daniel L.;Wahl, Angela
通讯作者：
Wahl, Angela