Dengue in Western Uganda: a prospective cohort of children presenting with undifferentiated febrile illness.
Dengue in Western Uganda: a prospective cohort of children presenting with undifferentiated febrile illness.
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DOI：
10.1186/s12879-020-05568-5
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发表时间：
2020-11-11
影响因子：
3.7
通讯作者：
Mulogo EM
中科院分区：
文献类型：
--
作者：
Boyce RM;Collins M;Muhindo R;Nakakande R;Ciccone EJ;Grounds S;Espinoza D;Zhu Y;Matte M;Ntaro M;Nyehangane D;Juliano JJ;Mulogo EM
撒哈拉以南非洲登革热的空间分布和负担仍然高度不确定，尽管生态适宜性很高。本研究的目的是描述登革热的流行病学队列的发热儿童门诊设施位于乌干达西部地区的城市化和疟疾传播强度的不同水平。首先使用快速诊断测试对符合条件的儿童进行疟疾筛查。使用NS 1/IgM/IgG快速检测组合（SD Bioline Dengue Duo）对疟疾结果为阴性的儿童进行登革热检测。在一个参与者子集中通过RT-PCR进行了确证性检测。进行抗原捕获ELISA以估计血清阳性率。1416名儿童中仅有6名（0.42%）登革热快速检测阳性，而RT-PCR结果均为阴性。ELISA检测显示，28名（2.2%）参与者中存在反应性IgG抗体，在姆巴拉拉城市站点的患病率最高（392人中的19人，4.9%，p < 0.001）。总的来说，这些发现表明，登革热，虽然存在，是一个不常见的原因，非疟疾，儿科发热性疾病在乌干达西部。迫切需要进一步调查在城市环境中维持低水平传播的生态学因素，以减少流行病的风险。在线版本包含补充材料，可通过10.1186/s12879-020-05568-5获得。
The spatial distribution and burden of dengue in sub-Saharan Africa remains highly uncertain, despite high levels of ecological suitability. The goal of this study was to describe the epidemiology of dengue among a cohort of febrile children presenting to outpatient facilities located in areas of western Uganda with differing levels of urbanicity and malaria transmission intensity. Eligible children were first screened for malaria using rapid diagnostic tests. Children with a negative malaria result were tested for dengue using a combination NS1/IgM/IgG rapid test (SD Bioline Dengue Duo). Confirmatory testing by RT-PCR was performed in a subset of participants. Antigen-capture ELISA was performed to estimate seroprevalence. Only 6 of 1416 (0.42%) children had a positive dengue rapid test, while none of the RT-PCR results were positive. ELISA testing demonstrated reactive IgG antibodies in 28 (2.2%) participants with the highest prevalence seen at the urban site in Mbarara (19 of 392, 4.9%, p < 0.001). Overall, these findings suggest that dengue, while present, is an uncommon cause of non-malarial, pediatric febrile illness in western Uganda. Further investigation into the eocological factors that sustain low-level transmission in urban settings are urgently needed to reduce the risk of epidemics. The online version contains supplementary material available at 10.1186/s12879-020-05568-5.
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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