Dengue virus infection in Africa.

Dengue virus infection in Africa.
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DOI:
10.3201/eid1708.101515
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发表时间:
2011-08
影响因子:
11.8
通讯作者:
Margolis HS
Margolis HS
中科院分区:
医学2区
文献类型:
--
作者:
Amarasinghe A;Kuritsk JN;Letson GW;Margolis HS

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近几十年来,全世界报告的登革热发病率有所增加,但对其在非洲的发病率知之甚少。1960-2010年期间,非洲共有22个国家报告了登革热的零星病例或暴发;非洲其他12个国家仅报告登革热在旅行者中。在有限的血清学调查中,疾病的存在和登革病毒抗体的高流行率表明,登革病毒在非洲所有或许多地区都有地方性感染。在非洲,登革热可能得不到充分认识和报告,原因是卫生保健提供者的认识较低,其他流行的发热性疾病,以及缺乏诊断检测和系统监测。解释低报告病例数量的其他假设包括对其他地方性黄病毒感染的交叉保护,防止感染或疾病的遗传宿主因素,以及低媒介能力和传播效率。需要以人群为基础的发热性疾病研究,以确定非洲登革热的流行病学和真实发病率。
Reported incidence of dengue has increased worldwide in recent decades, but little is known about its incidence in Africa. During 1960–2010, a total of 22 countries in Africa reported sporadic cases or outbreaks of dengue; 12 other countries in Africa reported dengue only in travelers. The presence of disease and high prevalence of antibody to dengue virus in limited serologic surveys suggest endemic dengue virus infection in all or many parts of Africa. Dengue is likely underrecognized and underreported in Africa because of low awareness by health care providers, other prevalent febrile illnesses, and lack of diagnostic testing and systematic surveillance. Other hypotheses to explain low reported numbers of cases include cross-protection from other endemic flavivirus infections, genetic host factors protecting against infection or disease, and low vector competence and transmission efficiency. Population-based studies of febrile illness are needed to determine the epidemiology and true incidence of dengue in Africa.
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