Free Radical Production and Characterization of Heat-Not-Burn Cigarettes in Comparison to Conventional and Electronic Cigarettes.
Free Radical Production and Characterization of Heat-Not-Burn Cigarettes in Comparison to Conventional and Electronic Cigarettes.
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DOI：
10.1021/acs.chemrestox.0c00088
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发表时间：
2020-07-20
影响因子：
4.1
通讯作者：
Richie, John P., Jr.
中科院分区：
文献类型：
--
作者：
Bitzer, Zachary T.;Goel, Reema;Trushin, Neil;Muscat, Joshua;Richie, John P., Jr.
对于传统香烟，燃烧锥达到>900°C的温度，导致产生许多有毒物质和大量高活性自由基。为了消除燃烧，同时仍然提供尼古丁和香料，一种更新的替代烟草产品出现了，称为“热不燃烧”（HnB）。这些产品将烟草加热到250-350°C的温度，这取决于设备，允许尼古丁和香料挥发，同时可能限制燃烧相关有毒物质的产生。为了更好地了解这些新产品的设计与传统香烟和不同风格的电子香烟（e-cigs）相比如何，我们测量并部分表征了它们的自由基产生。烟雾或气溶胶被捕获的自旋陷阱苯基-N-叔丁基硝酮（PBN）和分析的自由基使用电子顺磁共振（EPR）。通过在用PBN自旋捕获之前使气溶胶或烟雾通过极性或非极性捕集器来评估自由基极性。颗粒相的自由基只检测到传统的香烟。在所有产品的烟雾/气溶胶中检测到气相自由基，其中HnB（IQOS，Glo）（12 pmol/喷）的水平与电子烟（Juul，SREC，box mod e-cig）和混合装置（Ploom）（5-40 pmol/喷）相似，但比传统香烟（1 R6 F）低50倍。气相自由基的极性与HnB产品不同，与电子烟产生的自由基相比，传统香烟产生更多的极性自由基。在评价尼古丁输送产品的毒理学特征时应考虑自由基的产生，并且自由基的鉴别至关重要。
With conventional cigarettes, the burning cone reaches temperatures of >900°C resulting in the production of numerous toxicants and significant levels of highly reactive free radicals. In attempts to eliminate combustion while still delivering nicotine and flavorings, a newer alternative tobacco product has emerged known as “heat-not-burn” (HnB). These products heat tobacco to temperatures of 250–350°C depending on the device allowing for the volatilization of nicotine and flavorants while potentially limiting the production of combustion related toxicants. To better understand how the designs of these new products compare to conventional cigarettes and different styles of electronic cigarettes (e-cigs), we measured and partially characterized their production of free radicals. Smoke or aerosols were trapped by a spin trap phenyl-N-tert-butylnitrone (PBN) and analyzed for free radicals using electron paramagnetic resonance (EPR). Free radical polarity was assessed by passing the aerosol or smoke through either a polar or non-polar trap prior to being spin trapped with PBN. Particulate-phase radicals were detected only for conventional cigarettes. Gas-phase free radicals were detected in smoke/aerosol from all products with levels for HnB (IQOS, Glo) (12 pmol/puff) being similar to e-cigs (Juul, SREC, box mod e-cig) and hybrid devices (Ploom) (5–40 pmol/puff) but 50-fold lower than conventional cigarettes (1R6F). Gas phase radicals differed in polarity with HnB products and conventional cigarettes producing more polar radicals compared to those produced from e-cigs. Free radical production should be considered in evaluating the toxicological profile of nicotine delivery products and identification of the radicals is of paramount importance.
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影响因子：
4.3
作者：
Verschueren, Rik H.;Schmauck, Julie;Klussmann, Martin
通讯作者：
Klussmann, Martin
吸烟参数和烟草品种对自由基的影响在香烟主流烟雾中产生。
影响因子：
4.1
作者：
Goel R;Bitzer ZT;Reilly SM;Foulds J;Muscat J;Elias RJ;Richie JP Jr
通讯作者：
Richie JP Jr
影响因子：
4
作者：
Birru RL;Di YP
通讯作者：
Di YP
影响因子：
6
作者：
Tabuchi, Takahiro;Kiyohara, Kosuke;Kunugita, Naoki
通讯作者：
Kunugita, Naoki
影响因子：
4.1
作者：
Bitzer, Zachary T.;Goel, Reema;Richie, John P., Jr.
通讯作者：
Richie, John P., Jr.