Influence of Smoking Puff Parameters and Tobacco Varieties on Free Radicals Yields in Cigarette Mainstream Smoke.
Influence of Smoking Puff Parameters and Tobacco Varieties on Free Radicals Yields in Cigarette Mainstream Smoke.
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吸烟参数和烟草品种对自由基的影响在香烟主流烟雾中产生。
DOI：
10.1021/acs.chemrestox.8b00011
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发表时间：
2018-05-21
影响因子：
4.1
通讯作者：
Richie JP Jr
中科院分区：
文献类型：
--
作者：
Goel R;Bitzer ZT;Reilly SM;Foulds J;Muscat J;Elias RJ;Richie JP Jr
香烟烟雾是自由基的主要外源性来源，由此产生的氧化应激是吸烟引起的疾病的主要原因之一。然而，许多影响香烟自由基传递的因素仍不清楚。在这项研究中，我们机吸香烟和测量水平的气体和颗粒相自由基的电子顺磁共振（EPR）光谱使用标准化的吸烟方案（国际标准化组织（ISO）和加拿大强度（CI）），膨化参数，烟草混合物。与ISO方案相比，当香烟在CI方案下吸烟时，每支香烟的自由基递送在气体（4倍）和颗粒（6倍）相中均显著更大。每支香烟的总抽吸量是主要因素，自由基产生与总体积成比例，无论体积差异是否通过改变单个抽吸量或抽吸频率来实现。改变抽吸形状（钟形vs尖形vs方形）或抽吸持续时间（1-5 s），而不改变体积，对自由基产率没有影响。烟草品种对自由基产生有显著影响，其中气相自由基在再造烟叶>白肋烟>东方烟>明亮烟叶中最高，颗粒相自由基在白肋烟>明亮烟叶>东方烟>再造烟叶中最高。我们的研究结果表明，可修改的香烟设计特征和可测量的用户吸烟行为是决定吸烟者自由基暴露的关键因素。
Cigarette smoke is a major exogenous source of free radicals, and the resulting oxidative stress is one of the major causes of smoking-caused diseases. Yet, many of the factors that impact free radical delivery from cigarettes remain unclear. In this study, we machine-smoked cigarettes and measured the levels of gas- and particulate-phase radicals by electron paramagnetic resonance (EPR) spectroscopy using standardized smoking regimens (International Organization of Standardization (ISO) and Canadian Intense (CI)), puffing parameters, and tobacco blends. Radical delivery per cigarette was significantly greater in both gas (4-fold) and particulate (6-fold) phases when cigarettes were smoked under the CI protocol compared to the ISO protocol. Total puff volume per cigarette was the major factor with radical production being proportional to total volume, regardless of whether volume differences were achieved by changes in individual puff volume or puff frequency. Changing puff shape (bell vs sharp vs square) or puff duration (1–5 s), without changing volume, had no effect on radical yields. Tobacco variety did have a significant impact on free radical production, with gas-phase radicals highest in reconstituted > burley > oriental > bright tobacco and particulate-phase radicals highest in burley > bright > oriental > reconstituted tobacco. Our findings show that modifiable cigarette design features and measurable user smoking behaviors are key factors determining free radical exposure in smokers.
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影响因子：
3.8
作者：
Hammond, David;Fong, Geoffrey T.;McNeill, Ann
通讯作者：
McNeill, Ann
DOI：
10.1158/1055-9965.epi-09-1014
发表时间：
2009-12
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Marian C;O'Connor RJ;Djordjevic MV;Rees VW;Hatsukami DK;Shields PG
通讯作者：
Shields PG
DOI：
10.2478/10004-1254-64-2013-2250
发表时间：
2013-03-01
影响因子：
2.1
作者：
Djulancic, Nermina;Radojicic, Vesna;Srbinovska, Marija
通讯作者：
Srbinovska, Marija
影响因子：
5.1
作者：
Hoffmann, D;Djordjevic, MV;Hoffmann, I
通讯作者：
Hoffmann, I
影响因子：
3.4
作者：
Purkis, S. W.;Troude, V.;Hill, C. A.
通讯作者：
Hill, C. A.