Neurobehavioral assessment of infants born at term and in utero exposure to serotonin reuptake inhibitors.
Neurobehavioral assessment of infants born at term and in utero exposure to serotonin reuptake inhibitors.
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DOI：
10.1016/j.earlhumdev.2012.08.001
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发表时间：
2013-02
影响因子：
2.5
通讯作者：
Yonkers, Kimberly A.
中科院分区：
文献类型：
--
作者：
Smith, Megan V.;Sung, Anita;Shah, Bhavesh;Mayes, Linda;Klein, Deborah S.;Yonkers, Kimberly A.
一些研究报告了在子宫内接触血清素再摄取抑制剂（SRI）的新生儿的神经行为症状。然而，妊娠最后三个月的母亲精神疾病作为一个混杂因素，并不总是得到评估。在这项前瞻性研究中，我们比较了在妊娠最后三个月服用或未服用 SRI 的情绪正常女性所生的新生儿的神经行为并发症。对暴露和未暴露的婴儿进行以下评估： 1) 通过新生儿行为评估量表 (NBAS) 测量的气质； 2) 通过 Actiwatch 电子监控活动； 3) 使用训练有素的观察者对睡眠状态进行评级； 4) 通过病历审查了解围产期并发症。 T 检验、Fisher 精确检验和协方差分析用于评估临床和神经行为因素与暴露状态之间的关系。 67 名婴儿（61 名对照组和 6 名接受 SRI 的婴儿）。新生儿评估行为量表、APGAR 评分、婴儿睡眠状态（睡眠百分比、清醒百分比）、惊吓和颤抖、胎龄、出生体重和头围。与未暴露的婴儿相比，在妊娠晚期暴露于 SRI 的婴儿运动发育较差，5 分钟 APGAR 评分较低，平均孕龄较短。这项研究的结果显示，在控制活动性母亲精神疾病后，在子宫内接触或未接触 SRI 的新生儿之间自主神经和粗大运动活动存在差异。未来的纵向工作应该比较抑郁母亲暴露和未暴露的婴儿的长期结果。
Some studies report neurobehavioral symptoms in neonates exposed to serotonin reuptake inhibitors (SRIs) in utero. However, maternal psychiatric illness during the last trimester of pregnancy, as a confounding factor, has not always been assessed. In this prospective study we compared neurobehavioral complications among neonates who were born to euthymic women who either took or did not take an SRI during the last trimester of pregnancy. Exposed and unexposed infants were assessed for: 1) temperament as measured by the Neonatal Behavioral Assessment Scale (NBAS); 2) activity via Actiwatch electronic monitoring; 3) sleep state using trained observer ratings; and 4) perinatal complications through medical record review. T-tests, Fisher's exact tests, and analyses of covariance were used to assess the relationship between clinical and neurobehavioral factors and exposure status. 67 infants (61 controls and 6 exposed to SRIs). Neonatal Assessment Behavioral Scale, APGAR scores, infant sleep state (% sleep, % wakeful), startles and tremulousness, gestational age, birth weight, and head circumference. Infants exposed to SRIs in the third trimester had poorer motor development, lower 5-minute APGAR scores, and shorter mean gestational age as compared to unexposed infants. Results of this study show differences in autonomic and gross motor activity between neonates who were or were not exposed to SRIs in utero after controlling for active maternal psychiatric illness. Future longitudinal work should compare longer term outcomes of exposed and unexposed infants of depressed mothers.
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影响因子：
9.8
作者：
Cooper, William O.;Willy, Mary E.;Ray, Wayne A.
通讯作者：
Ray, Wayne A.
影响因子：
--
作者：
Oberlander, Tim F.;Warburton, William;Hertzman, Clyde
通讯作者：
Hertzman, Clyde
影响因子：
5.3
作者：
Sheehan, DV;Lecrubier, Y;Dunbar, GC
通讯作者：
Dunbar, GC
影响因子：
4.6
作者：
LESTER, BM;ALS, H;BRAZELTON, TB
通讯作者：
BRAZELTON, TB
影响因子：
--
作者：
Levison-Castiel, R;Merlob, P;Klinger, G
通讯作者：
Klinger, G