Multifunctional receptor stabilin-1 in homeostasis and disease.
Multifunctional receptor stabilin-1 in homeostasis and disease.
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DOI：
10.1100/tsw.2010.189
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发表时间：
2010-10-12
影响因子：
--
通讯作者：
Kzhyshkowska J
中科院分区：
文献类型：
--
作者：
Kzhyshkowska J
多功能清道夫受体稳定蛋白-1(STAB1，Feel-1，Clear-1，KIAA0246)在健康生物的组织巨噬细胞和窦状内皮细胞上表达，在慢性炎症和肿瘤进展过程中，其在巨噬细胞和不同亚型内皮细胞上的表达均被诱导。STABBILIN-1是一种1型跨膜受体，它介导细胞内和吞噬细胞对不需要的自身成分的清除，介导内源性合成的几丁质酶样蛋白SI-CLP的细胞内分选，以及生长激素家族成员胎盘催乳素的跨细胞作用。稳定蛋白-1贩运的中央分拣站似乎是跨高尔基网络(TGN)。稳定蛋白-1在TGN中的运输需要与GGA适配器相互作用，GGA适配器与经典的DDSLL基序结合，并在其细胞质尾部形成一个新的酸性簇。稳定素-1的降解似乎依赖于与分选连接蛋白17的相互作用。然而，将稳定素-1保持在细胞表面的机制仍未确定。这个问题值得特别关注，因为越来越多的数据表明，稳定素-1在细胞黏附事件中的作用在炎症和转移中是必不可少的。考虑到稳定蛋白-1介导的过程的复杂性，在动物模型中研究稳定蛋白-1的功能，以及细胞内运输和细胞外接触的数学模型，将使预测稳定蛋白-1在复杂生物系统中的行为成为可能，并将为慢性炎症和癌症发生中稳定蛋白-1通路的治疗靶向开辟新的前景。
The multifunctional scavenger receptor stabilin-1 (STAB1, FEEL-1, CLEVER-1, KIAA0246) is expressed on tissue macrophages and sinusoidal endothelial cells in healthy organisms, and its expression on both macrophages and different subtypes of endothelial cells is induced during chronic inflammation and tumor progression. Stabilin-1 is a type-1 transmembrane receptor that mediates endocytic and phagocytic clearance of “unwanted-self” components, intracellular sorting of the endogenously synthesized chitinase-like protein SI-CLP, and transcytosis of the growth hormone family member placental lactogen. The central sorting station for stabilin-1 trafficking seems to be the trans-Golgi network (TGN). Transport of stabilin-1 in the TGN requires interaction with GGA adaptors that bind to the classical DDSLL motif and a novel acidic cluster in its cytoplasmic tail. Degradation of stabilin-1 seems to depend on the interaction with sorting nexin 17. However, the mechanisms keeping stabilin-1 on the cell surface remain to be identified. This issue deserves specific attention due to the growing amount of data indicating that function of stabilin-1 in cell adhesion events is essential for inflammation and metastasis. Taking into consideration the complexity of stabilin-1—mediated processes, investigation of stabilin-1 functions in the animal models, as well as mathematic modeling of intracellular trafficking and extracellular contact, would enable prediction of stabilin-1 behavior in complex biological systems and would open perspectives for therapeutic targeting of stabilin-1 pathways in chronic inflammation and carcinogenesis.
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影响因子：
2.3
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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