The assessment of myometrium perfusion in patients with uterine fibroid by arterial spin labeling MRI.
The assessment of myometrium perfusion in patients with uterine fibroid by arterial spin labeling MRI.
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DOI：
10.1186/s40064-016-3596-0
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Osuga Y
中科院分区：
文献类型：
--
作者：
Takahashi N;Yoshino O;Hiraike O;Maeda E;Nakamura M;Hori M;Harada M;Koga K;Saito S;Fujii T;Osuga Y
有人认为，子宫肌瘤引起的血液供应不足可能会导致生育能力下降。因此，子宫血流量的定量评估可能是不孕症治疗的一个很好的工具。第一步，通过测量子宫肌肉层的血流量来检查在盆腔器官中进行动脉自旋标记 (ASL)-MRI 的能力。三名正常志愿者女性、七名患有子宫肌瘤的患者和四名接受 GnRH 类似物治疗子宫肌瘤的患者参加了这项研究。使用非增强 ASL-MRI 检查正常子宫肌层的灌注。感兴趣的区域设置在子宫肌层中，其中一个点位于髂腰肌或臀肌中。 ASL灌注指数计算为（子宫ASL值-髂腰肌/臀肌ASL值）。 3名志愿者分泌期ASL灌注指数均显着低于增殖期指数（P<0.05）。在肌瘤患者中，包括所有三种类型的肌瘤（浆膜下型、壁内型和粘膜下型）。 7例单发子宫肌瘤患者中，肌瘤阳性侧子宫肌层ASL灌注指数较肌瘤阴性侧增加4.9倍。通过 GnRH 类似物治疗，子宫肌层的 ASL 灌注平均下降至 39%（P < 0.05）。我们利用 ASL-MRI 技术来评估子宫肌层的灌注。在临床应用中，已知子宫肌瘤引起的血液供应不足会导致生育能力下降。 ASL-MRI 技术可能有助于评估血液供应，作为子宫肌瘤患者生育力的定量测量。
It has been suggested that an inadequate blood supply caused by uterine fibroids may lead to decreasing fertility. Therefore, a quantitative evaluation of blood flow in the uterus might be a good tool for infertility treatments. For the first step, the ability to perform arterial spin labeling (ASL)-MRI in pelvic organs was examined by measuring blood flow in the uterine muscle layer. Three normal volunteer women, seven patients with one uterine fibroid and four patients treated with GnRH analogue for uterine fibroids, were enrolled in this study. Perfusion of normal uterine myometrium was examined using non-enhanced ASL-MRI. The region of interest was set in the uterine muscle layer, with a point in the iliopsoas or gluteus muscle. The ASL perfusion index was calculated as (ASL value in uterus—ASL value in iliopsoas/gluteus muscle). The ASL perfusion indexes in the secretory phase of all 3 volunteers were significantly lower than the indexes in the proliferative phases (P < 0.05). In patients with fibroids, all three types of fibroids (subserosal, intramural and submucosal types) were included. In seven patients harboring a single uterine fibroid, the ASL perfusion indexes of myometrium on the fibroid-positive side increased 4.9 fold compared with that of the fibroid-negative side. With GnRH analogue treatment, ASL perfusion in myometrium decreased to 39% on average (P < 0.05). We utilized the ASL-MRI technique to evaluate perfusion of uterine myometrium. For clinical use, an inadequate blood supply caused by uterine fibroids is known to lead to decreasing fertility. The ASL-MRI technique might be useful to evaluate blood supply as a quantitative measurement of fertility in patients with uterine fibroids.
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影响因子：
3.4
作者：
DELIGDISH, L;LOEWENTHAL, M
通讯作者：
LOEWENTHAL, M
影响因子：
4.4
作者：
Wang, JJ;Licht, DJ;Detre, JA
通讯作者：
Detre, JA
影响因子：
2.1
作者：
Alatas, C;Aksoy, E;Bahceci, M
通讯作者：
Bahceci, M
DOI：
10.1016/0002-9378(90)90983-e
发表时间：
1990-03-01
影响因子：
9.8
作者：
DEVRIES, K;LYONS, EA;LINDSAY, DJ
通讯作者：
LINDSAY, DJ
影响因子：
6.1
作者：
Raine-Fenning, NJ;Campbell, BK;Johnson, IR
通讯作者：
Johnson, IR