Dynamics of salivary human herpesvirus‐6 and ‐7 shedding in pregnant women
Dynamics of salivary human herpesvirus‐6 and ‐7 shedding in pregnant women
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孕妇唾液人类疱疹病毒‐6 和‐7 脱落动态
DOI：
10.1002/jmv.27692
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发表时间：
2022
影响因子：
12.7
通讯作者：
Yoshikawa Tetsushi
中科院分区：
文献类型：
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作者：
Suzuki Noriko;Ihira Masaru;Enya Yasuko;Yumi Takahashi;Izuru Chisato;Rie Igarashi;Higashimoto Yuki;Hiroki Miura;Asaki Takanashi;Kaoru Fujimoto;Kawamura Yoshiki;Yoshikawa Tetsushi
乙型疱疹病毒（人类疱疹病毒6A: HHV‐6A，‐6B, HHV‐7）的再激活可能与精神疾病和宿主疲劳有关。本研究旨在确定通过监测唾液病毒DNA载量测量的病毒再激活是否可用于监测孕妇和产后妇女的抑郁症。在五个观察期收集64名孕妇的唾液样本。采用HHV‐6和HHV‐7特异性qpcr检测病毒DNA载量。当在唾液中检测到HHV‐6 DNA时，采用巢式PCR区分HHV‐6A和‐6B。在这两种病毒中，检测频率与唾液中的病毒DNA载量之间存在显著相关性。在低脱落组中，HHV‐6 DNA在妊娠晚期（p< 0.0001）、分娩时（p= 0.0003）、出生后1个月（p= 0.0023）与妊娠早期相比显著升高，HHV‐7在分娩时（p= 0.0277）和出生后1个月（p= 0.0235）显著升高。唾液中检测到的HHV - 6 dna大部分为HHV - 6B。在爱丁堡产后抑郁量表（EPDS）得分异常的受试者中，两种病毒DNA载量均显著降低（HHV‐6:p= 0.0101, HHV‐7:p= 0.0044）。妊娠晚期后，唾液中两种病毒的检出率和病毒DNA载量均增加。唾液病毒DNA脱落在EPDS评分异常的受试者中显著降低。
Reactivation ofBetaherpesvirinae(Human herpesvirus 6A: HHV‐6A, ‐6B, HHV‐7) may be associated with mental illness and host fatigue. This study aimed to determine whether viral reactivation, measured by monitoring salivary viral DNA load, can be used to monitor depression in pregnant and postpartum women. Saliva samples were collected from 64 pregnant women at five points of observation periods. The HHV‐6‐ and HHV‐7‐specific qPCRs were carried out to measure viral DNA load. When HHV‐6 DNA was detected in saliva, nested PCR was used to discriminate between HHV‐6A and ‐6B. In both viruses, a significant correlation was observed between detection frequency and viral DNA load in saliva. In the low‐shedding group, HHV‐6 DNA was significantly higher in the third trimester (p< 0.0001), the time of delivery (p= 0.0003), 1 month after birth (p= 0.0023) compared with the first trimester, and HHV‐7 was at the time of delivery (p= 0.0277) and 1 month after birth (p= 0.0235). Most of the detected HHV‐6 DNAs in saliva were HHV‐6B. Both viral DNA loads were significantly lower (HHV‐6:p= 0.0101, HHV‐7:p= 0.0044) in the subjects with abnormal Edinburgh Postnatal Depression Scale (EPDS) scores. The detection rate and viral DNA load of both viruses in saliva increased after the third trimester. Salivary virus DNA shedding was significantly lower in subjects with an abnormal EPDS score.
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影响因子：
2.2
作者：
Park, Jeong-Hwan;Karmaus, Wilfried;Zhang, Hongmei
通讯作者：
Zhang, Hongmei
孕妇和非孕妇的宫颈巨细胞病毒排泄：妊娠早期的抑制。
影响因子：
6.4
作者：
S. Stagno;D. Reynolds;A. Tsiantos;D. Fuccillo;R. Smith;M. Tiller;C. Alford
通讯作者：
C. Alford
Tanaka N 等人：“在不相关的脐带血移植中监测四种疱疹病毒。”骨髓移植。
DOI：
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发表时间：
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影响因子：
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聚合酶链式反应检测急疹患者及其母亲多个身体部位样本中的人类疱疹病毒 6 DNA
影响因子：
12.7
作者：
S. Suga;T. Yazaki;Y. Kajita;T. Ozaki;Y. Asano
通讯作者：
Y. Asano
影响因子：
8
作者：
Suga, S;Yoshikawa, T;Asano, Y
通讯作者：
Asano, Y