Physiological and behavioral changes in honey bees (Apis mellifera) induced by Nosema ceranae infection.
Physiological and behavioral changes in honey bees (Apis mellifera) induced by Nosema ceranae infection.
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DOI：
10.1371/journal.pone.0058165
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Spivak M
中科院分区：
文献类型：
--
作者：
Goblirsch M;Huang ZY;Spivak M
持续接触螨虫、营养不良、杀虫剂和病原体威胁着蜜蜂的生存。在健康的蜂群中，卵黄前体蛋白卵黄蛋白原 (Vg) 和内分泌因子保幼激素 (JH) 之间的相互作用，起到起搏器的作用，驱动工蜂一生中所执行的一系列行为。幼蜂在蜂巢内履行护理职责，具有高 Vg 和低 JH；随着年龄较大的蜜蜂转向觅食，这种趋势会发生逆转。病原体和寄生虫可以改变这个调节网络。例如，小孢子虫、蜜蜂微孢子虫的感染已被证明可以促进工人的行为成熟。我们研究了最近的蜜蜂病原体感染对工人劳动分工生理因素的影响。与对照组相比，感染了中华蜜蜂的蜜蜂进行早熟觅食的可能性几乎是对照组的两倍，并且平均寿命缩短了 9 天。我们还表明，在笼中受感染的养蜂中，Vg 转录物较低，而 JH 滴度却升高。这种表达模式是非典型的，与健康、未感染的蜜蜂的预期相反。由于感染而导致的时间性多民族性的基本基础的破坏可能是最近蜂群死亡率高的一个因素，因为工蜂可能会失去对蜂群需求反应的灵活性。
Persistent exposure to mite pests, poor nutrition, pesticides, and pathogens threaten honey bee survival. In healthy colonies, the interaction of the yolk precursor protein, vitellogenin (Vg), and endocrine factor, juvenile hormone (JH), functions as a pacemaker driving the sequence of behaviors that workers perform throughout their lives. Young bees perform nursing duties within the hive and have high Vg and low JH; as older bees transition to foraging, this trend reverses. Pathogens and parasites can alter this regulatory network. For example, infection with the microsporidian, Nosema apis, has been shown to advance behavioral maturation in workers. We investigated the effects of infection with a recent honey bee pathogen on physiological factors underlying the division of labor in workers. Bees infected with N. ceranae were nearly twice as likely to engage in precocious foraging and lived 9 days less, on average, compared to controls. We also show that Vg transcript was low, while JH titer spiked, in infected nurse-aged bees in cages. This pattern of expression is atypical and the reverse of what would be expected for healthy, non-infected bees. Disruption of the basic underpinnings of temporal polyethism due to infection may be a contributing factor to recent high colony mortality, as workers may lose flexibility in their response to colony demands.
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影响因子：
3.7
作者：
Calderone NW
通讯作者：
Calderone NW
影响因子：
64.8
作者：
Amdam, GV;Csondes, A;Page, RE
通讯作者：
Page, RE
影响因子：
2
作者：
Karina Medici, Sandra;Gabriel Sarlo, Edgardo;Javier Eguaras, Martin
通讯作者：
Javier Eguaras, Martin
影响因子：
2.6
作者：
LIU, TP
通讯作者：
LIU, TP
DOI：
10.1073/pnas.0333979100
发表时间：
2003-02-18
影响因子：
11.1
作者：
Amdam, GV;Norberg, K;Omholt, SW
通讯作者：
Omholt, SW