Translational Implication of Galectin-9 in the Pathogenesis and Treatment of Viral Infection.
Translational Implication of Galectin-9 in the Pathogenesis and Treatment of Viral Infection.
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DOI：
10.3390/ijms18102108
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发表时间：
2017-10-08
影响因子：
5.6
通讯作者：
Ho LJ
中科院分区：
文献类型：
--
作者：
Lai JH;Luo SF;Wang MY;Ho LJ
半乳糖凝集素-9及其受体Tim-3之间的相互作用引发了一系列调节免疫反应的信号传导事件。已证明半乳凝素-9的表达在许多不同病毒的多种靶细胞中增加，例如丙型肝炎病毒（HCV）、B肝炎病毒（HBV）、单纯疱疹病毒（HSV）、流感病毒、登革热病毒（DENV）和人类免疫缺陷病毒（HIV）。病毒感染后半乳糖凝集素-9的这种增强表达促进了病毒感染细胞行为的显著变化，并且所产生的事件与病毒疾病的免疫发病机制密切相关。由于人类对不同病毒感染的免疫反应可能会有所不同，并且缺乏适当的治疗可能会产生潜在的致命后果，因此了解半乳糖凝集素-9的影响对于开发更好的监测和治疗病毒感染的方法至关重要。本文旨在探讨如何应用目前对半乳糖凝集素-9功能的认识，以更好地了解病毒感染的发病机制，更好地治疗病毒性疾病。
The interaction between galectin-9 and its receptor, Tim-3, triggers a series of signaling events that regulate immune responses. The expression of galectin-9 has been shown to be increased in a variety of target cells of many different viruses, such as hepatitis C virus (HCV), hepatitis B virus (HBV), herpes simplex virus (HSV), influenza virus, dengue virus (DENV), and human immunodeficiency virus (HIV). This enhanced expression of galectin-9 following viral infection promotes significant changes in the behaviors of the virus-infected cells, and the resulting events tightly correlate with the immunopathogenesis of the viral disease. Because the human immune response to different viral infections can vary, and the lack of appropriate treatment can have potentially fatal consequences, understanding the implications of galectin-9 is crucial for developing better methods for monitoring and treating viral infections. This review seeks to address how we can apply the current understanding of galectin-9 function to better understand the pathogenesis of viral infection and better treat viral diseases.
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影响因子：
8.8
作者：
Chagan-Yasutan, Haorile;Ndhlovu, Lishomwa C.;Lacuesta, Talitha Lea;Kubo, Toru;Leano, Prisca Susan A.;Niki, Toshiro;Oguma, Shigeru;Morita, Kouichi;Chew, Glen. M.;Barbour, Jason D.;Telan, Elizabeth Freda O.;Hirashima, Mitsuomi;Hattori, Toshio;Dimaano, Efren M.
通讯作者：
Dimaano, Efren M.
影响因子：
5.6
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Masaki T
影响因子：
6.7
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Abdel-Mohsen M;Chavez L;Tandon R;Chew GM;Deng X;Danesh A;Keating S;Lanteri M;Samuels ML;Hoh R;Sacha JB;Norris PJ;Niki T;Shikuma CM;Hirashima M;Deeks SG;Ndhlovu LC;Pillai SK
通讯作者：
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影响因子：
30.5
作者：
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通讯作者：
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影响因子：
2.8
作者：
Hirashima, M
通讯作者：
Hirashima, M