Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection.
Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection.
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DOI：
10.1016/j.jcv.2013.10.022
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发表时间：
2013-12
影响因子：
8.8
通讯作者：
Dimaano, Efren M.
中科院分区：
文献类型：
--
作者：
Chagan-Yasutan, Haorile;Ndhlovu, Lishomwa C.;Lacuesta, Talitha Lea;Kubo, Toru;Leano, Prisca Susan A.;Niki, Toshiro;Oguma, Shigeru;Morita, Kouichi;Chew, Glen. M.;Barbour, Jason D.;Telan, Elizabeth Freda O.;Hirashima, Mitsuomi;Hattori, Toshio;Dimaano, Efren M.
登革病毒（DENV）感染仍然是全球主要的公共卫生负担。可溶性介质可能在急性登革病毒感染的发病机制中起关键作用。半乳糖凝集素-9（Galectin-9，Gal-9）是一种可溶性β-半乳糖苷结合凝集素，具有多种免疫调节和炎症特性。研究血浆Gal-9水平作为DENV感染的生物标志物。我们在2010年菲律宾流行期间招募了65名DENV感染患者，并在疾病的关键阶段和恢复阶段测量了他们的血浆Gal-9和细胞因子/趋化因子水平、DENV基因型和拷贝数。在关键阶段，与健康或患有非登革热发热性疾病的患者相比，DENV感染患者中的Gal-9水平显著更高。在登革出血热（DHF）患者中观察到最高的Gal-9水平（DHF：2464 pg/ml;登革热患者（DF）：1407 pg/ml;非登革热发热性疾病：616 pg/ml;健康：196 pg/ml）。在恢复期，Gal-9水平从DF和DHF患者的峰值水平显著下降。Gal-9水平追踪病毒载量，并与多种细胞因子和趋化因子（IL-1α、IL-8、IP-10和VEGF）相关，包括单核细胞频率和凝血的血液学变量。进一步判别分析显示，Eotaxin、Gal-9、IFN-α2和MCP-1对DHF和DF的特异性分别为92%和79.3%（P<0.01）。Gal-9似乎跟踪DENV炎症反应，因此，它可以作为急性DENV感染和疾病严重程度的重要新生物标志物。
Dengue virus (DENV) infection remains a major public health burden worldwide. Soluble mediators may play a critical role in the pathogenesis of acute DENV infection. Galectin-9 (Gal-9) is a soluble β-galactoside-binding lectin, with multiple immunoregulatory and inflammatory properties. To investigate plasma Gal-9 levels as a biomarker for DENV infection. We enrolled 65 DENV infected patients during the 2010 epidemic in the Philippines and measured their plasma Gal-9 and cytokine/chemokine levels, DENV genotypes, and copy number during the critical and recovery phases of illness. During the critical phase, Gal-9 levels were significantly higher in DENV infected patients compared to healthy or those with non-dengue febrile illness. The highest Gal-9 levels were observed in dengue hemorrhagic fever (DHF) patients (DHF: 2464 pg/ml; dengue fever patients (DF): 1407 pg/ml; non-dengue febrile illness: 616 pg/ml; healthy: 196 pg/ml). In the recovery phase, Gal-9 levels significantly declined from peak levels in DF and DHF patients. Gal-9 levels tracked viral load, and were associated with multiple cytokines and chemokines (IL-1α, IL-8, IP-10, and VEGF), including monocyte frequencies and hematologic variables of coagulation. Further discriminant analyses showed that eotaxin, Gal-9, IFN-α2, and MCP-1 could detect 92% of DHF and 79.3% of DF, specifically (P<0.01). Gal-9 appears to track DENV inflammatory responses, and therefore, it could serve as an important novel biomarker of acute DENV infection and disease severity.
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DOI：
10.4269/ajtmh.1999.60.693
发表时间：
1999-04-01
影响因子：
3.3
作者：
Vaughn, DW;Nisalak, A;Devine, PL
通讯作者：
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影响因子：
4.8
作者：
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影响因子：
3
作者：
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DOI：
10.4269/ajtmh.2012.11-0606
发表时间：
2012-11-01
影响因子：
3.3
作者：
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影响因子：
3.7
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