NEAT1 as a competing endogenous RNA in tumorigenesis of various cancers: Role, mechanism and therapeutic potential.
NEAT1 as a competing endogenous RNA in tumorigenesis of various cancers: Role, mechanism and therapeutic potential.
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DOI：
10.7150/ijbs.62728
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发表时间：
2021
影响因子：
9.2
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Li K;Yao T;Zhang Y;Li W;Wang Z
核旁斑组装转录物1（NEAT 1）是一种长链非编码RNA（lncRNA），在多种人类癌症类型中上调。越来越多的证据表明，癌细胞中NEAT 1的升高促进细胞生长、迁移和侵袭，并抑制细胞凋亡。还已知lncRNA作为竞争性内源性RNA（ceRNA）通过海绵状微小RNA（miRNA）来改变其靶基因在癌症发展中的表达水平。因此，重要的是要了解这种观察的分子机制。在这篇综述中，特别强调了NEAT 1在肿瘤发展中的作用。我们还总结和讨论了NEAT 1/miRNA/靶标网络在各种癌症进展中的反馈作用。随着我们对NEAT 1在肿瘤发生过程中作用的理解的提高，其作为癌症生物标志物和/或靶标的治疗潜力也变得更加清晰。
The nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) that is upregulated in a variety of human cancer types. Increasing evidence has shown that the elevation of NEAT1 in cancer cells promotes cell growth, migration, and invasion and inhibits cell apoptosis. It is also known that lncRNAs act as a competing endogenous RNA (ceRNA) by sponging microRNAs (miRNAs) to alter the expression levels of their target genes in the development of cancers. Therefore, it is important to understand the molecular mechanisms underlying this observation. In this review, specific emphasis was placed on NEAT1's role in tumor development. We also summarize and discuss the feedback roles of NEAT1/miRNA/target network in the progression of various cancers. As our understanding of the role of NEAT1 during tumorigenesis improves, its therapeutic potential as a biomarker and/or target for cancer also becomes clearer.
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影响因子：
4
作者：
Gao, Ming;Liu, Liying;Chang, Zhiwei
通讯作者：
Chang, Zhiwei
影响因子：
4
作者：
An J;Lv W;Zhang Y
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作者：
Ding N;Wu H;Tao T;Peng E
通讯作者：
Peng E
DOI：
10.26355/eurrev_202005_21170
发表时间：
2020-05-01
影响因子：
3.3
作者：
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通讯作者：
Lin, H.
影响因子：
5.6
作者：
Braga EA;Fridman MV;Moscovtsev AA;Filippova EA;Dmitriev AA;Kushlinskii NE
通讯作者：
Kushlinskii NE