A randomized crossover trial of HEPA air filtration to reduce cardiovascular risk for near highway residents: Methods and approach.
A randomized crossover trial of HEPA air filtration to reduce cardiovascular risk for near highway residents: Methods and approach.
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HEPA空气过滤降低高速公路附近居民心血管风险的随机交叉试验：方法和途径
DOI：
10.1016/j.cct.2021.106520
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发表时间：
2021-09
影响因子：
2.2
通讯作者：
Eliasziw M
中科院分区：
文献类型：
--
作者：
Brugge D;Lerman Ginzburg S;Hudda N;Sprague Martinez L;Meunier L;Hersey SP;Hochman I;Walker DI;Echevarria B;Thanikachalam M;Durant JL;Zamore W;Eliasziw M
高速公路附近的居民暴露于高水平的交通相关空气污染（TRAP），包括超细颗粒物，这与不利的健康影响有关。使用家用空气过滤装置减少暴露并可能产生健康益处的功效尚未在随机对照试验中进行测试。我们将在美国马萨诸塞州萨默维尔的200名30岁及以上居住在高速公路附近住宅的成年人中进行一项便携式空气过滤装置的随机双盲交叉试验。我们将从172个家庭中招募参与者。干预期为1个月的真实或假滤过，随后为1个月的洗脱期，然后为1个月的替代干预。主要健康结局将是收缩压（BP）;次要结局指标将包括舒张压和中心血压、C反应蛋白（CRP）和D-二聚体。干预成功或失败的原因将在一组家庭中进行评估，使用室内/室外颗粒污染监测，个人监测，颗粒污染的大小和组成，跟踪在房间内使用过滤器的时间，以及定性反馈的访谈。这项试验已经开始招募，预计需要2 - 3年才能完成。由于COVID-19疫情需要采取额外预防措施，招聘工作尤其具有挑战性。这项研究有可能揭示在靠近高速公路的家庭中使用便携式空气过滤器以减少TRAP暴露的价值，以及这样做是否对心血管健康有益。
Near highway residents are exposed to elevated levels of traffic-related air pollution (TRAP), including ultrafine particles, which are associated with adverse health effects. The efficacy of using in-home air filtration units that reduce exposure and potentially yield health benefits has not been tested in a randomized controlled trial. We will conduct a randomized double-blind crossover trial of portable air filtration units for 200 adults 30 years and older who live in near-highway homes in Somerville, MA, USA. We will recruit participants from 172 households. The intervention periods will be one month of true or sham filtration, followed by a one-month wash out period and then a month of the alternate intervention. The primary health outcome will be systolic blood pressure (BP); secondary outcome measures will include diastolic and central BP, C-Reactive Protein (CRP) and D-dimer. Reasons for success or failure of the intervention will be evaluated in a subset of homes using indoor/outdoor monitoring for particulate pollution, personal monitoring, size and composition of particulate pollution, tracking of time spent in the room with the filter, and interviews for qualitative feedback. This trial has begun recruitment and is expected to take 2–3 years to be completed. Recruitment has been particularly challenging because of additional precautions required by the COVID-19 pandemic. This study has the potential to shed light on the value of using portable air filtration in homes close to highways to reduce exposure to TRAP and whether doing so has benefits for cardiovascular health.
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影响因子：
8.3
作者：
Kingsley SL;Eliot MN;Whitsel EA;Wang Y;Coull BA;Hou L;Margolis HG;Margolis KL;Mu L;Wu WC;Johnson KC;Allison MA;Manson JE;Eaton CB;Wellenius GA
通讯作者：
Wellenius GA
用木炉房中的空气过滤单元减少室内空气污染物。
DOI：
10.1016/j.scitotenv.2017.03.111
发表时间：
2017-08-15
期刊：
The Science of the total environment
影响因子：
--
作者：
McNamara ML;Thornburg J;Semmens EO;Ward TJ;Noonan CW
通讯作者：
Noonan CW
影响因子：
4.5
作者：
Lane KJ;Levy JI;Scammell MK;Patton AP;Durant JL;Mwamburi M;Zamore W;Brugge D
通讯作者：
Brugge D
影响因子：
5
作者：
Hofman, J.;Staelens, J.;Roekens, E.
通讯作者：
Roekens, E.
影响因子：
4.4
作者：
Chanel, Olivier;Perez, Laura;Medina, Sylvia
通讯作者：
Medina, Sylvia