Neuromelanin magnetic resonance imaging reveals increased dopaminergic neuron activity in the substantia nigra of patients with schizophrenia.
Neuromelanin magnetic resonance imaging reveals increased dopaminergic neuron activity in the substantia nigra of patients with schizophrenia.
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神经元素磁共振成像显示，精神分裂症患者的黑质中多巴胺能神经元活性增加。
DOI：
10.1371/journal.pone.0104619
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Tomiyama N
中科院分区：
文献类型：
--
作者：
Watanabe Y;Tanaka H;Tsukabe A;Kunitomi Y;Nishizawa M;Hashimoto R;Yamamori H;Fujimoto M;Fukunaga M;Tomiyama N
多巴胺假说认为，过量的多巴胺释放导致精神分裂症的症状。本研究的目的是利用3-T神经黑素磁共振成像（MRI）阐明精神分裂症患者和健康对照者的多巴胺能和去甲肾上腺素能神经元。我们前瞻性研究了52例精神分裂症患者（男：女= 27∶25，平均年龄35岁）和年龄、性别匹配的健康对照。 使用3 T MRI单元，我们获得了垂直于脑干的倾斜T1加权轴向图像。我们测量了黑质（SNc）、中脑被盖、蓝斑（LC）和脑桥的信号强度和面积。然后，我们计算了SNc（CRSN）和LC（CRLC）的对比率（CR），并使用非配对t检验在患者和健康对照组之间进行比较。SNc和LC在患者和健康对照组中均容易被识别为大脑脚后部和脑桥被盖上部的高信号强度区域。患者CRSN值显著高于健康对照组（10.89±2.37 vs.9.6 ±2.36，p<0.01）。我们观察到患者和健康对照之间的CRLC值没有差异（14.21±3.5 vs. 13.44±3.37，p = 0.25）。 此外，SNc和LC的面积在精神分裂症患者和对照组之间没有差异。神经黑素MRI可显示精神分裂症患者SNc信号增强。我们的研究结果表明，这些患者的SNc中存在过量的多巴胺产物。
The dopamine hypothesis suggests that excessive dopamine release results in the symptoms of schizophrenia. The purpose of this study was to elucidate the dopaminergic and noradrenergic neurons using 3-T neuromelanin magnetic resonance imaging (MRI) in patients with schizophrenia and healthy control subjects. We prospectively examined 52 patients with schizophrenia (M: F = 27∶25, mean age, 35 years) and age- and sex-matched healthy controls. Using a 3T MRI unit, we obtained oblique T1-weighted axial images perpendicular to the brainstem. We measured the signal intensity and area for the substantia nigra (SNc), midbrain tegmentum, locus ceruleus (LC), and pons. We then calculated the contrast ratios (CR) for the SNc (CRSN) and LC (CRLC), which were compared between patients and healthy controls using unpaired t-tests. The SNc and LC were readily identified in both patients and healthy controls as areas with high signal intensities in the posterior part of the cerebral peduncle and in the upper pontine tegmentum. The CRSN values in patients were significantly higher than those in healthy controls (10.89±2.37 vs. 9.6±2.36, p<0.01). We observed no difference in the CRLC values between the patients and healthy controls (14.21±3.5 vs. 13.44±3.37, p = 0.25). Furthermore, there was no difference in area of the SNc and LC between schizophrenia patients and controls. Neuromelanin MRI might reveal increased signal intensity in the SNc of patients with schizophrenia. Our results indicate the presence of excessive dopamine products in the SNc of these patients.
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影响因子：
10.6
作者：
Shibata, Eri;Sasaki, Makoto;Sakai, Akio
通讯作者：
Sakai, Akio
影响因子：
2.5
作者：
Ohtsuka, Chigumi;Sasaki, Makoto;Terayama, Yasuo
通讯作者：
Terayama, Yasuo
影响因子：
2.8
作者：
Ogisu, Kimihiro;Kudo, Kohsuke;Shirato, Hiroki
通讯作者：
Shirato, Hiroki
影响因子：
11.9
作者：
Matsuoka, Keiko;Uno, Masatake;Kim, Yoshiharu
通讯作者：
Kim, Yoshiharu
DOI：
10.2463/mrms.5.197
发表时间：
2006-12-01
期刊：
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
影响因子：
--
作者：
Shibata, Eri;Sasaki, Makoto;Sakai, Akio
通讯作者：
Sakai, Akio