Neighbourhood deprivation across eight decades and late-life cognitive function in the Lothian Birth Cohort 1936: a life-course study.
Neighbourhood deprivation across eight decades and late-life cognitive function in the Lothian Birth Cohort 1936: a life-course study.
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DOI：
10.1093/ageing/afad056
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发表时间：
2023-04-01
期刊：
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
--
作者：
虽然邻里关系可以预测晚年的认知功能，但研究大多依赖于单一时间点的测量，很少有采用生命过程方法的调查。此外，目前还不清楚邻里和认知测试成绩之间的关联是否与特定的认知领域或一般能力有关。这项研究探讨了80年来邻里剥夺如何影响晚年认知功能。数据来自1936年洛锡安出生队列（n = 1，091），在70、73、76、79和82岁时通过10次测试测量认知功能。参与者的居住历史是通过“生命网格”问卷收集的，并与儿童、青年和成年中后期的邻里剥夺有关。协会进行了测试与潜在的增长曲线模型的水平和斜率的一般（g）和特定领域的能力（视觉空间能力，记忆和处理速度），和生命历程的协会进行了探索与路径分析。较高的成年中后期邻里剥夺与较低的70岁水平（β =-0.113，95%置信区间[CI]：-0.205，-0.021）和12年内g下降较快（β =-0.160，95% CI：-0.290，-0.031）相关。特定领域认知功能（例如处理速度）的最初明显发现是由于它们与g的共同差异。路径分析表明，童年邻里的不利间接联系到晚年的认知功能，通过较低的教育和选择性的住宅流动性。据我们所知，我们提供了最全面的评估生活过程中的邻里剥夺和认知老化的关系。在成年中后期生活在认知功能不全的地区可能直接有助于改善认知功能和减缓衰退，而童年时期的邻里关系可能会通过认知储备影响功能。
although neighbourhood may predict late-life cognitive function, studies mostly rely on measurements at a single time point, with few investigations applying a life-course approach. Furthermore, it is unclear whether the associations between neighbourhood and cognitive test scores relate to specific cognitive domains or general ability. This study explored how neighbourhood deprivation across eight decades contributed to late-life cognitive function. data were drawn from the Lothian Birth Cohort 1936 (n = 1,091) with cognitive function measured through 10 tests at ages 70, 73, 76, 79 and 82. Participants’ residential history was gathered with ‘lifegrid’ questionnaires and linked to neighbourhood deprivation in childhood, young adulthood and mid-to-late adulthood. Associations were tested with latent growth curve models for levels and slopes of general (g) and domain-specific abilities (visuospatial ability, memory and processing speed), and life-course associations were explored with path analysis. higher mid-to-late adulthood neighbourhood deprivation was associated with lower age 70 levels (β = −0.113, 95% confidence intervals [CI]: −0.205, −0.021) and faster decline of g over 12 years (β = −0.160, 95%CI: −0.290, −0.031). Initially apparent findings with domain-specific cognitive functions (e.g. processing speed) were due to their shared variance with g. Path analyses suggested that childhood neighbourhood disadvantage is indirectly linked to late-life cognitive function through lower education and selective residential mobility. to our knowledge, we provide the most comprehensive assessment of the life-course neighbourhood deprivation and cognitive ageing relationship. Living in advantaged areas in mid-to-late adulthood may directly contribute to better cognitive function and slower decline, whereas an advantaged childhood neighbourhood likely affects functioning through cognitive reserves.
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影响因子：
5.6
作者：
Clarke PJ;Weuve J;Barnes L;Evans DA;Mendes de Leon CF
通讯作者：
Mendes de Leon CF
影响因子：
4.1
作者：
Deary IJ;Gow AJ;Taylor MD;Corley J;Brett C;Wilson V;Campbell H;Whalley LJ;Visscher PM;Porteous DJ;Starr JM
通讯作者：
Starr JM
DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
影响因子：
5.7
作者：
Deary, IJ;Simonotto, E;Wardlaw, JM
通讯作者：
Wardlaw, JM
影响因子：
6.8
作者：
Hamilton OKL;Cox SR;Okely JA;Conte F;Ballerini L;Bastin ME;Corley J;Taylor AM;Page D;Gow AJ;Muñoz Maniega S;Redmond P;Valdés-Hernández MDC;Wardlaw JM;Deary IJ
通讯作者：
Deary IJ