Extracellular vesicles: potential roles in regenerative medicine.
Extracellular vesicles: potential roles in regenerative medicine.
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DOI：
10.3389/fimmu.2014.00608
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发表时间：
2014
影响因子：
7.3
通讯作者：
Verhaar MC
中科院分区：
文献类型：
--
作者：
De Jong OG;Van Balkom BW;Schiffelers RM;Bouten CV;Verhaar MC
胞外囊泡由外泌体和微囊泡组成，外泌体是在多泡体与细胞膜融合时释放的，微囊泡是直接从细胞膜释放的。EV可以介导细胞间的通讯，并参与许多过程，包括免疫信号、血管生成、应激反应、衰老、增殖和细胞分化。EV参与的大量过程以及它们可以影响受体细胞行为的多功能性使EV成为治疗和诊断应用的有趣来源。肿瘤生物学和免疫学领域的成功激发了EV在再生医学领域潜力的探索。事实上，EV参与组织和器官损伤的恢复，并可能部分解释在干细胞治疗方法中观察到的旁分泌效应。EV的功能和内容也可能包含可用于组织工程的信息，在组织工程中，旁分泌信号被用来调节细胞募集、分化和增殖。本文综述了EV在再生医学中的功能和作用，并对其在组织工程中的潜在应用进行了阐述。
Extracellular vesicles (EV) consist of exosomes, which are released upon fusion of the multivesicular body with the cell membrane, and microvesicles, which are released directly from the cell membrane. EV can mediate cell–cell communication and are involved in many processes, including immune signaling, angiogenesis, stress response, senescence, proliferation, and cell differentiation. The vast amount of processes that EV are involved in and the versatility of manner in which they can influence the behavior of recipient cells make EV an interesting source for both therapeutic and diagnostic applications. Successes in the fields of tumor biology and immunology sparked the exploration of the potential of EV in the field of regenerative medicine. Indeed, EV are involved in restoring tissue and organ damage, and may partially explain the paracrine effects observed in stem cell-based therapeutic approaches. The function and content of EV may also harbor information that can be used in tissue engineering, in which paracrine signaling is employed to modulate cell recruitment, differentiation, and proliferation. In this review, we discuss the function and role of EV in regenerative medicine and elaborate on potential applications in tissue engineering.
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影响因子：
4.8
作者：
Akyurekli, Celine;Le, Yevgeniya;Allan, David S.
通讯作者：
Allan, David S.
影响因子：
3.7
作者：
Bruno S;Grange C;Collino F;Deregibus MC;Cantaluppi V;Biancone L;Tetta C;Camussi G
通讯作者：
Camussi G
影响因子：
3.7
作者：
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通讯作者：
Hu JC
影响因子：
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作者：
Borschel, GH;Huang, YC;Brown, DL
通讯作者：
Brown, DL
影响因子：
3.3
作者：
Cantaluppi, Vincenzo;Biancone, Luigi;Camussi, Giovanni
通讯作者：
Camussi, Giovanni