The development of sleep-wake rhythms and the search for elemental circuits in the infant brain.
The development of sleep-wake rhythms and the search for elemental circuits in the infant brain.
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DOI：
10.1037/a0035891
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发表时间：
2014-06
影响因子：
1.9
通讯作者：
Todd WD
中科院分区：
文献类型：
--
作者：
Blumberg MS;Gall AJ;Todd WD
尽管睡眠在婴儿早期占主导地位，但发育科学尚未在形成有关睡眠及其相关的超昼夜节律和昼夜节律的概念和理论方面发挥重要作用。在这里，我们认为，发展分析有助于我们阐明脑干和前脑的相对贡献，睡眠-觉醒控制和解剖的神经成分的睡眠-觉醒节律。发育分析也清楚地表明，婴儿的睡眠-觉醒过程是成人睡眠-觉醒过程的基础。例如，婴儿脑干本身就包含一个基本的睡眠-觉醒回路，足以在清醒、安静睡眠和活跃睡眠之间产生过渡。此外，与睡眠-觉醒过程的"触发器"模型的要求一致，这种脑干回路支持状态之间的快速转换。在发育后期，加强脑干和前脑之间的双向相互作用有助于巩固睡眠和清醒发作，制定睡眠稳态过程，以及昼夜节律的出现。发展的角度在这里提出严格限制理论的睡眠-觉醒控制，并提供了一个必要的框架，为创建完全实现的计算模型。最后，通过更好地理解这个系统是如何在发育过程中构建的，我们将深入了解由于衰老和疾病而导致其解体的过程。
Despite the predominance of sleep in early infancy, developmental science has yet to play a major role in shaping concepts and theories about sleep and its associated ultradian and circadian rhythms. Here we argue that developmental analyses help us to elucidate the relative contributions of the brainstem and forebrain to sleep-wake control and to dissect the neural components of sleep-wake rhythms. Developmental analysis also makes it clear that sleep-wake processes in infants are the foundation for those of adults. For example, the infant brainstem alone contains a fundamental sleep-wake circuit that is sufficient to produce transitions among wakefulness, quiet sleep, and active sleep. Also, consistent with the requirements of a “flip-flop” model of sleep-wake processes, this brainstem circuit supports rapid transitions between states. Later in development, strengthening bidirectional interactions between the brainstem and forebrain contribute to the consolidation of sleep and wake bouts, the elaboration of sleep homeostatic processes, and the emergence of diurnal or nocturnal circadian rhythms. The developmental perspective promoted here critically constrains theories of sleep-wake control and provides a needed framework for the creation of fully realized computational models. Finally, with a better understanding of how this system is constructed developmentally, we will gain insight into the processes that govern its disintegration due to aging and disease.
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影响因子：
56.9
作者：
CHASE, MH;MORALES, FR
通讯作者：
MORALES, FR
影响因子：
3.5
作者：
Gall, Andrew J.;Todd, William D.;Blumberg, Mark S.
通讯作者：
Blumberg, Mark S.
影响因子：
25
作者：
Deboer, T;Vansteensel, MJ;Meijer, JH
通讯作者：
Meijer, JH
影响因子：
3.4
作者：
Blumberg, Mark S
通讯作者：
Blumberg, Mark S
影响因子：
64.5
作者：
Chemelli, RM;Willie, JT;Yanagisawa, M
通讯作者：
Yanagisawa, M